U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25743, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Kcnj6provided by RGD
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 6provided by RGD
Primary source
RGD:2959
See related
EnsemblRapid:ENSRNOG00000001658 AllianceGenome:RGD:2959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G-protein alpha-subunit binding activity. Involved in cellular response to morphine and response to electrical stimulus. Located in several cellular components, including cell surface; dendrite; and neuronal cell body membrane. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 38.3), Heart (RPKM 5.9) and 1 other tissue See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kcnj6 in Genome Data Viewer
Location:
11q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (47531312..47778348, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (34061702..34308758, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (35011007..35262362, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1A Neighboring gene uncharacterized LOC120095638 Neighboring gene uncharacterized LOC102550239 Neighboring gene uncharacterized LOC134481061 Neighboring gene uncharacterized LOC120095639 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 22 Neighboring gene uncharacterized LOC108352313

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain. Bond CT, et al. FEBS Lett, 1995 Jun 19. PMID 7601286
  2. Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Stoffel M, et al. Biochem Biophys Res Commun, 1995 Jul 26. PMID 7626127
  3. Potassium channel mRNAs with AU-rich elements and brain-specific expression. Suda S, et al. Biochem Biophys Res Commun, 2002 Mar 15. PMID 11883954
  4. Inwardly rectifying potassium channels in rat retinal ganglion cells. Chen L, et al. Eur J Neurosci, 2004 Aug. PMID 15305864
  5. Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel. Koike-Tani M, et al. J Physiol, 2005 Apr 15. PMID 15731196, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of Mitochondrial KATP Channels in the Infarct-Reducing Effect of Normobaric Hypoxia.
    Title: The Role of Mitochondrial K(ATP) Channels in the Infarct-Reducing Effect of Normobaric Hypoxia.
  2. Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1A and PPAR-gamma pathway.
    Title: Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
  3. Study is first to show direct cleavage of GIRK1 and GIRK2 subunits by caspase-3, with cleavage sites in GIRK1 (387ECLD390) and GIRK2 (349YEVD352) and suggests the possible role of caspase-3 mediated down-regulation of GIRK channel function and expression in hippocampal neuronal injury during prolonged epileptic seizures.
    Title: Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
  4. The opening of ATP-sensitive K+ channels protects cardiomyocytes against the high glucose-induced injury and inflammation by inhibiting the ROS-TLR4-necroptosis pathway.
    Title: The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
  5. inwardly rectifying K+ channels coupled to 5-HT1A autoreceptors display pharmacological properties generally expected for neuronal GIRK channels, but different from GIRK1-GIRK2 heteromers
    Title: Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
  6. Fourteen days after axotomy, GIRK1 and GIRK2 were down-regulated in DRG neurons at the mRNA and protein levels.
    Title: G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.
  7. Data describe the developmental regulation and subcellular diversity of neuronal GIRK/Kir3 channels, and support the contention that distinct subpopulations of GIRK channels exert separable influences on neuronal excitability.
    Title: Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.
  8. Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
    Title: Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.
  9. The mutant, Gbeta1(W332A) protein, although inactive, retains its ability to bind Kir3 and prevents the wild type Gbeta from activating the channel.
    Title: Dominant negative effects of a Gbeta mutant on G-protein coupled inward rectifier K+ channel.
  10. the KCNJ6 rs2070995 AA genotype association with increased opioid requirements extends from analgesia to opiate substitution therapy
    Title: A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size.
Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein activated inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables G-protein activated inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to morphine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G protein-activated inward rectifier potassium channel 2
Names
BIR1
GIRK-2
GIRK2
KATP-2
inward rectifier K(+) channel Kir3.2
potassium channel, inwardly rectifying subfamily J member 6
potassium voltage-gated channel subfamily J member 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393803.2 → NP_001380732.1  G protein-activated inward rectifier potassium channel 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P48550
    UniProtKB/TrEMBL
    A0A9K3Y8C1, F1LS53, Q8QZW1
    Related
    ENSRNOP00000059308.2, ENSRNOT00000066940.4
    Conserved Domains (2) summary
    pfam01007
    Location:59 → 198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205 → 374
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. NM_013192.4 → NP_037324.1  G protein-activated inward rectifier potassium channel 2 isoform 1

    See identical proteins and their annotated locations for NP_037324.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P48550
    UniProtKB/TrEMBL
    A0A8I6G5I5, Q54A91
    Related
    ENSRNOP00000079589.1, ENSRNOT00000119355.2
    Conserved Domains (2) summary
    pfam01007
    Location:59 → 198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205 → 374
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    47531312..47778348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270313.1 → XP_063126383.1  G protein-activated inward rectifier potassium channel 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G5I5, Q54A91
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48550.1 GenPept UniProtKB/Swiss-Prot:P48550

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous