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SHC2 SHC adaptor protein 2 [ Homo sapiens (human) ]

Gene ID: 25759, updated on 14-Nov-2024

Summary

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Official Symbol
SHC2provided by HGNC
Official Full Name
SHC adaptor protein 2provided by HGNC
Primary source
HGNC:HGNC:29869
See related
Ensembl:ENSG00000129946 MIM:605217; AllianceGenome:HGNC:29869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCK; SLI; SHCB
Summary
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 10.2), gall bladder (RPKM 9.1) and 24 other tissues See more
Orthologs
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Genomic context

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See SHC2 in Genome Data Viewer
Location:
19p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (416589..461033, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (364869..412538, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (416589..461033, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:406130-407009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:407010-407890 Neighboring gene proline-rich proteoglycan 2-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:412911-413666 Neighboring gene C2 calcium dependent domain containing 4C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:427767-428344 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:428871-430070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:436243-436744 Neighboring gene RNA, 5S ribosomal pseudogene 462 Neighboring gene MPRA-validated peak3210 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:470349-470886 Neighboring gene CIMAP1 family member D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:485653-486171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9600 Neighboring gene uncharacterized LOC124904608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:489477-489978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9602 Neighboring gene MADCAM1 antisense RNA 1 Neighboring gene mucosal vascular addressin cell adhesion molecule 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Kavanaugh WM, et al. Science, 1994 Dec 16. PMID 7527937
  2. SHC2 gene copy number in multiple system atrophy (MSA). Ferguson MC, et al. Clin Auton Res, 2014 Feb. PMID 24170347, Free PMC Article
  3. Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. Sasaki H, et al. Mol Brain, 2011 Jun 10. PMID 21658278, Free PMC Article
  4. CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. Teodorczyk M, et al. Cell Death Differ, 2015 Jul. PMID 25613377, Free PMC Article
  5. Sck interacts with KDR and Flt-1 via its SH2 domain. Igarashi K, et al. Biochem Biophys Res Commun, 1998 Oct 9. PMID 9790910

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sck was identified as a novel molecule indispensable for CD95's activation of the PI3K and MAPK pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma.
    Title: CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.
  2. SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population.
    Title: SHC2 gene copy number in multiple system atrophy (MSA).
  3. Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy.
    Title: Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SHC-transforming protein 2
Names
SH2 domain protein C2
SHC (Src homology 2 domain containing) transforming protein 2
SHC-transforming protein B
neuronal Shc adaptor homolog
protein Sck
src homology 2 domain-containing-transforming protein C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387056.1 → NP_001373985.1  SHC-transforming protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC006124, AC008988, AC138433
    Conserved Domains (2) summary
    cd09925
    Location:434 → 537
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:138 → 307
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  2. NM_012435.3 → NP_036567.2  SHC-transforming protein 2 isoform 1

    See identical proteins and their annotated locations for NP_036567.2

    Status: VALIDATED

    Source sequence(s)
    AC006124, AC008988, AC138433
    Consensus CDS
    CCDS45891.1
    UniProtKB/Swiss-Prot
    O60230, P98077, Q9NPL5, Q9UCX4
    Related
    ENSP00000264554.4, ENST00000264554.11
    Conserved Domains (2) summary
    cd09925
    Location:479 → 582
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:138 → 307
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    416589..461033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527894.3 → XP_011526196.1  SHC-transforming protein 2 isoform X2

    Conserved Domains (2) summary
    cd01209
    Location:138 → 307
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    cl15255
    Location:434 → 497
    SH2; Src homology 2 (SH2) domain

  2. XM_011527893.4 → XP_011526195.1  SHC-transforming protein 2 isoform X1

    Conserved Domains (2) summary
    cd01209
    Location:138 → 307
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    cl15255
    Location:479 → 542
    SH2; Src homology 2 (SH2) domain

  3. XM_011527896.3 → XP_011526198.1  SHC-transforming protein 2 isoform X3

    Conserved Domains (2) summary
    cd01209
    Location:1 → 150
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    cl15255
    Location:322 → 385
    SH2; Src homology 2 (SH2) domain

  4. XM_047438565.1 → XP_047294521.1  SHC-transforming protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    364869..412538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320469.1 → XP_054176444.1  SHC-transforming protein 2 isoform X4

  2. XM_054320470.1 → XP_054176445.1  SHC-transforming protein 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98077.4 GenPept UniProtKB/Swiss-Prot:P98077

Gene LinkOut

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