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PARM1 prostate androgen-regulated mucin-like protein 1 [ Homo sapiens (human) ]

Gene ID: 25849, updated on 2-Nov-2024

Summary

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Official Symbol
PARM1provided by HGNC
Official Full Name
prostate androgen-regulated mucin-like protein 1provided by HGNC
Primary source
HGNC:HGNC:24536
See related
Ensembl:ENSG00000169116 MIM:617688; AllianceGenome:HGNC:24536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WSC4; Cipar1; PARM-1; DKFZP564O0823
Summary
Located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thyroid (RPKM 83.3), colon (RPKM 61.9) and 21 other tissues See more
Orthologs
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Genomic context

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See PARM1 in Genome Data Viewer
Location:
4q13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (74933116..75050113)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (78273250..78390252)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (75858326..75975323)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377280 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:75811383-75812582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15479 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21615 Neighboring gene PARM1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr4:75916580-75917081 Neighboring gene NANOG hESC enhancer GRCh37_chr4:75951718-75952258 Neighboring gene uncharacterized LOC107986289 Neighboring gene long intergenic non-protein coding RNA 2562 Neighboring gene Sharpr-MPRA regulatory region 9565 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76052289-76052985 Neighboring gene uncharacterized LOC100506253 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:76106257-76106757

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer. Liu YR, et al. J Cell Biochem, 2019 Oct. PMID 31297877
  2. Characterization and identification of PARM-1 as a new potential oncogene. Charfi C, et al. Mol Cancer, 2013 Jul 31. PMID 23902727, Free PMC Article
  3. Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias. Wittler L, et al. Gene, 2012 Sep 15. PMID 22766399
  4. A novel gene overexpressed in the prostate of castrated rats: hormonal regulation, relationship to apoptosis and to acquired prostatic cell androgen independence. Bruyninx M, et al. Endocrinology, 1999 Oct. PMID 10499539
  5. Prostatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation. Cornet AM, et al. Prostate, 2003 Aug 1. PMID 12772192

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer.
    Title: Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer.
  2. Our results strongly suggest the oncogenic potential of PARM-1.
    Title: Characterization and identification of PARM-1 as a new potential oncogene.
  3. PARM1 does not play a major role in the development of epispadias
    Title: Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Ectopic expression of hPARM-1 in PC3 prostate cancer cells increased colony formation, suggesting a probable role in cell proliferation.
    Title: Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prostate androgen-regulated mucin-like protein 1
Names
WSC4, cell wall integrity and stress response component 4 homolog
castration-induced prostatic apoptosis-related protein 1
prostatic androgen-regulated mucin-like protein 1
prostatic androgen-repressed message 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015393.4 → NP_056208.2  prostate androgen-regulated mucin-like protein 1 precursor

    See identical proteins and their annotated locations for NP_056208.2

    Status: VALIDATED

    Source sequence(s)
    AC098825, AC110760, AI767320
    Consensus CDS
    CCDS47077.1
    UniProtKB/Swiss-Prot
    B3KMQ9, Q6UWI2, Q96DV8, Q9Y4S1
    Related
    ENSP00000370224.3, ENST00000307428.7
    Conserved Domains (1) summary
    pfam17061
    Location:15 → 310
    PARM; PARM

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    74933116..75050113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531833.1 → XP_011530135.1  prostate androgen-regulated mucin-like protein 1 isoform X1

    Conserved Domains (1) summary
    pfam17061
    Location:50 → 345
    PARM; PARM

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    78273250..78390252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349619.1 → XP_054205594.1  prostate androgen-regulated mucin-like protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWI2.1 GenPept UniProtKB/Swiss-Prot:Q6UWI2

Gene LinkOut

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