Or51e1 olfactory receptor family 51 subfamily E member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or51e1provided by MGI
Official Full Name: olfactory receptor family 51 subfamily E member 1provided by MGI
Primary source: MGI:MGI:3030392
See related: Ensembl:ENSMUSG00000070423 AllianceGenome:MGI:3030392
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: POGR; MOR18-1; Olfr558
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 3.6), heart adult (RPKM 2.0) and 9 other tissues See more
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Genomic context

Location:: 7 E3; 7 54.81 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (102351530..102361261)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102702323..102712054)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Key amino acids alter activity and trafficking of a well-conserved olfactory receptor.
Title: Key amino acids alter activity and trafficking of a well-conserved olfactory receptor.
Three olfactory receptors (olfr544, olfr558, and olfr1386) were expressed in the olfactory marker protein (+) cells of the bladder and thyroid.
Title: Olfactory marker protein expression is an indicator of olfactory receptor-associated events in non-olfactory tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olfactory receptor family 51 subfamily E member 1

Names: GA_x6K02T2PBJ9-5425951-5426904; olfactory receptor 558; olfactory receptor MOR18-1; prostate overexpressed G protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_147093.3 → NP_667304.1 olfactory receptor family 51 subfamily E member 1

See identical proteins and their annotated locations for NP_667304.1

Status: PROVISIONAL

Source sequence(s)

AK141545

Consensus CDS

CCDS21543.1

UniProtKB/TrEMBL

Q3B876, Q8VGZ7

Related

ENSMUSP00000091674.4, ENSMUST00000094124.5

Conserved Domains (1) summary

cd15222
Location:27 → 300

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

102351530..102361261

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507877.4 → XP_006507940.1 olfactory receptor family 51 subfamily E member 1 isoform X1

See identical proteins and their annotated locations for XP_006507940.1

UniProtKB/TrEMBL

Q3B876, Q8VGZ7

Conserved Domains (1) summary

cd15222
Location:27 → 300

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors