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malt2 MALT paracaspase 2 [ Danio rerio (zebrafish) ]

Gene ID: 259196, updated on 9-Dec-2024

Summary

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Official Symbol
malt2provided by ZNC
Official Full Name
MALT paracaspase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-020801-2
See related
Ensembl:ENSDARG00000006052 AllianceGenome:ZFIN:ZDB-GENE-020801-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
malt1; malt1a; pcasp2
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See malt2 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (15706081..15717943, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (15679699..15691823, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-396h14.1 Neighboring gene scaffold attachment factor B Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene family with sequence similarity 32 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Uren AG, et al. Mol Cell, 2000 Oct. PMID 11090634
  2. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. Ung CY, et al. BMC Genomics, 2010 Mar 30. PMID 20353558, Free PMC Article
  3. MALT1 is not alone after all: identification of novel paracaspases. Hulpiau P, et al. Cell Mol Life Sci, 2016 Mar. PMID 26377317, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MALT paracaspase 2
Names
MALT1 paracaspase a
mucosa associated lymphoid tissue lymphoma translocation gene 1
mucosa associated lymphoid tissue lymphoma translocation gene 1a
paracaspace
paracaspase-2
pcasp1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152976.1 → NP_694508.1  MALT paracaspase 2

    See identical proteins and their annotated locations for NP_694508.1

    Status: PROVISIONAL

    Source sequence(s)
    AF316598
    UniProtKB/TrEMBL
    A0A8M1PDS9, Q9DDL2
    Related
    ENSDARP00000020264.8, ENSDART00000008424.10
    Conserved Domains (5) summary
    smart00410
    Location:112 → 181
    IG_like; Immunoglobulin like
    pfam07679
    Location:211 → 288
    I-set; Immunoglobulin I-set domain
    cd08783
    Location:8 → 102
    Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
    pfam00656
    Location:323 → 526
    Peptidase_C14; Caspase domain
    pfam13895
    Location:214 → 276
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    15706081..15717943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161701.5 → XP_005161758.1  MALT paracaspase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B8H7
    Conserved Domains (5) summary
    smart00410
    Location:112 → 181
    IG_like; Immunoglobulin like
    pfam07679
    Location:207 → 284
    I-set; Immunoglobulin I-set domain
    cd08783
    Location:8 → 102
    Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
    pfam00656
    Location:319 → 522
    Peptidase_C14; Caspase domain
    pfam13895
    Location:210 → 272
    Ig_2; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395099.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    3458..15274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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