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NGDN neuroguidin [ Homo sapiens (human) ]

Gene ID: 25983, updated on 2-Nov-2024

Summary

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Official Symbol
NGDNprovided by HGNC
Official Full Name
neuroguidinprovided by HGNC
Primary source
HGNC:HGNC:20271
See related
Ensembl:ENSG00000129460 MIM:610777; AllianceGenome:HGNC:20271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGD; LCP5; CANu1; lpd-2; C14orf120
Summary
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 17.4), ovary (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

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See NGDN in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23469703..23478826)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17670297..17679414)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23938912..23948035)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23884455-23885654 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23893609-23894808 Neighboring gene microRNA 208b Neighboring gene myosin heavy chain 7 Neighboring gene myosin heavy chain associated RNA transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23904729-23905566 Neighboring gene VISTA enhancer hs1670 Neighboring gene VISTA enhancer hs2330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5609 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:23938675-23939615 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23951280-23952037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23952038-23952794 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:23963206-23963906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23993935-23994786 Neighboring gene thiamine triphosphatase Neighboring gene uncharacterized LOC124903289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24001492-24001992 Neighboring gene zinc finger homeobox 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24006625-24007504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24014522-24015146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24017019-24017642 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24019766-24020428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24024860-24025794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24031286-24031786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24031787-24032287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8176 Neighboring gene AP1G2 antisense RNA 1 Neighboring gene adaptor related protein complex 1 subunit gamma 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs. Chen K, et al. J Hematol Oncol, 2015 Feb 19. PMID 25887473, Free PMC Article
  2. CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. Sihn CR, et al. Genes Cells, 2008 Aug. PMID 18547334
  3. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. Jung MY, et al. Mol Cell Biol, 2006 Jun. PMID 16705177, Free PMC Article
  4. An orthogonal proteomic survey uncovers novel Zika virus host factors. Scaturro P, et al. Nature, 2018 Sep. PMID 30177828
  5. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Udagawa T, et al. Mol Cell, 2012 Jul 27. PMID 22727665, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the results of this study in vitro confirmed that NGDN over-expression can increase the sensitivity of human myeloid multidrug-resistant leukemia cells to chemotherapeutic drugs
    Title: High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs.
  2. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
    Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
  3. Study isolated a novel human gene, to be called as CANu1, by the large-scale genome-wide association analysis to screen specific Single nucleotide polymorphisms in colon cancer.
    Title: CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564O092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation at postsynapse IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perforant pathway to dendrate granule cell synapse IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuroguidin
Names
EIF4E-binding protein
centromere accumulated nuclear protein 1
eukaryotic initiation factor 4E and CPEB binding protein
neuroguidin, EIF4E binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042635.2 → NP_001036100.1  neuroguidin isoform 1

    See identical proteins and their annotated locations for NP_001036100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL132855, BC030817
    Consensus CDS
    CCDS41926.1
    UniProtKB/Swiss-Prot
    A8K760, Q8NEJ9, Q9Y400
    UniProtKB/TrEMBL
    H0YJQ1
    Related
    ENSP00000386134.3, ENST00000408901.8
    Conserved Domains (1) summary
    pfam04000
    Location:18 → 97
    Sas10_Utp3; Sas10/Utp3/C1D family

  2. NM_015514.2 → NP_056329.1  neuroguidin isoform 2

    See identical proteins and their annotated locations for NP_056329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron, differing in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL132855
    Consensus CDS
    CCDS32051.1
    UniProtKB/TrEMBL
    H0YJQ1
    Related
    ENSP00000380340.3, ENST00000397154.7
    Conserved Domains (1) summary
    pfam04000
    Location:18 → 97
    Sas10_Utp3; Sas10/Utp3/C1D family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23469703..23478826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17670297..17679414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375789.1 → XP_054231764.1  neuroguidin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEJ9.1 GenPept UniProtKB/Swiss-Prot:Q8NEJ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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