U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trim61 tripartite motif-containing 61 [ Mus musculus (house mouse) ]

Gene ID: 260296, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Trim61provided by MGI
Official Full Name
tripartite motif-containing 61provided by MGI
Primary source
MGI:MGI:2387432
See related
Ensembl:ENSMUSG00000109718 AllianceGenome:MGI:2387432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf35; 2czf61; E330039K03Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to be active in cytosol. Is expressed in central nervous system; early conceptus; secondary oocyte; and testis. Orthologous to human TRIM61 (tripartite motif containing 61). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in ovary adult (RPKM 1.5) and kidney adult (RPKM 0.2) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Trim61 in Genome Data Viewer
Location:
8 B3.1; 8 32.52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65465628..65471340, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (65012976..65018688, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 192 Neighboring gene tripartite motif-containing 75 Neighboring gene tripartite motif-containing 60 Neighboring gene STARR-seq mESC enhancer starr_21646 Neighboring gene apelin receptor early endogenous ligand Neighboring gene STARR-seq mESC enhancer starr_21647 Neighboring gene predicted gene, 39183 Neighboring gene STARR-seq mESC enhancer starr_21648 Neighboring gene STARR-seq mESC enhancer starr_21650 Neighboring gene STARR-seq mESC enhancer starr_21651

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos. Choo KB, et al. Nucleic Acids Res, 2002 Nov 15. PMID 12433986, Free PMC Article
  2. Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression. Chen HH, et al. Genomics, 2002 Aug. PMID 12160726
  3. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. Huang CJ, et al. J Biol Chem, 2005 Sep 2. PMID 15994318
  4. Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF. Huang CJ, et al. Biochem J, 2005 Apr 15. PMID 15516209, Free PMC Article
  5. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Yu C, et al. Cell Res, 2016 Mar. PMID 26902285, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the Rnf35 promoter is negatively modulated by the repressor element, DER, and that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux.
    Title: Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence.
  2. Regulation of transcription and pre-mRNA processing of Rnf35 in eggs and in pre-implantation embryos.
    Title: Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos.
  3. Rnf33 and Rnf35 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing.
    Title: Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative tripartite motif-containing protein 61
Names
ring finger protein 35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177551.1 → NP_001171022.1  putative tripartite motif-containing protein 61

    See identical proteins and their annotated locations for NP_001171022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK054544, BB709545, CF175045
    Consensus CDS
    CCDS22332.1
    UniProtKB/TrEMBL
    Q6P242, Q8JZK6
    Related
    ENSMUSP00000077513.4, ENSMUST00000078409.5
    Conserved Domains (2) summary
    cd15828
    Location:272 → 456
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    cl17238
    Location:16 → 56
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_153110.4 → NP_694750.3  putative tripartite motif-containing protein 61

    See identical proteins and their annotated locations for NP_694750.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK054544, BB709545, BC064738, CF175045
    Consensus CDS
    CCDS22332.1
    UniProtKB/TrEMBL
    Q6P242, Q8JZK6
    Conserved Domains (2) summary
    cd15828
    Location:272 → 456
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    cl17238
    Location:16 → 56
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    65465628..65471340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools