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FAM169A family with sequence similarity 169 member A [ Homo sapiens (human) ]

Gene ID: 26049, updated on 27-Nov-2024

Summary

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Official Symbol
FAM169Aprovided by HGNC
Official Full Name
family with sequence similarity 169 member Aprovided by HGNC
Primary source
HGNC:HGNC:29138
See related
Ensembl:ENSG00000198780 MIM:615769; AllianceGenome:HGNC:29138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLAP; SLAP75
Summary
Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 10.3), testis (RPKM 7.3) and 15 other tissues See more
Orthologs
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Genomic context

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See FAM169A in Genome Data Viewer
Location:
5q13.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (74777574..74866966, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (75258467..75347878, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74073399..74162791, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:73936823-73937538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:73937539-73938252 Neighboring gene Sharpr-MPRA regulatory region 10699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22671 Neighboring gene ectodermal-neural cortex 1 Neighboring gene hexosaminidase subunit beta Neighboring gene ReSE screen-validated silencer GRCh37_chr5:73973961-73974139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:73980770-73981270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:74001994-74002494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:74002495-74002995 Neighboring gene RNA, U6 small nuclear 658, pseudogene Neighboring gene GTP dependent ribosome recycling factor mitochondrial 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22675 Neighboring gene RNA, U6 small nuclear 1330, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:74090248-74090748 Neighboring gene NSA2 ribosome biogenesis factor Neighboring gene ARPC1A pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:74110781-74111468 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:74112436-74113179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16097 Neighboring gene FAM169A antisense RNA 1 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:74178519-74179391 Neighboring gene uncharacterized LOC105379039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Manipulation of the nuclear envelope-associated protein SLAP during mammalian brain development affects cortical lamination and exploratory behavior. Mestres I, et al. Biol Open, 2024 Mar 1. PMID 38466184, Free PMC Article
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485
  3. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. Roux KJ, et al. J Cell Biol, 2012 Mar 19. PMID 22412018, Free PMC Article
  4. An investigation into the human serum "interactome". Zhou M, et al. Electrophoresis, 2004 May. PMID 15174051
  5. Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. Hannigan MM, et al. Mol Cell Proteomics, 2020 Nov. PMID 32788342, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0888

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
soluble lamin-associated protein of 75 kDa
Names
Soluble-Lamin Associated Protein
protein FAM169A
soluble lamina-associated protein of 75 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376049.1 → NP_001362978.1  soluble lamin-associated protein of 75 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214
    Consensus CDS
    CCDS43330.1
    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4
    UniProtKB/TrEMBL
    D6RB01
    Related
    ENSP00000508577.1, ENST00000687041.1

  2. NM_001376050.1 → NP_001362979.1  soluble lamin-associated protein of 75 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214
    Consensus CDS
    CCDS43330.1
    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4
    UniProtKB/TrEMBL
    D6RB01

  3. NM_001376051.1 → NP_001362980.1  soluble lamin-associated protein of 75 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214
    Consensus CDS
    CCDS43330.1
    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4
    UniProtKB/TrEMBL
    D6RB01

  4. NM_001376052.1 → NP_001362981.1  soluble lamin-associated protein of 75 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214
    Consensus CDS
    CCDS43330.1
    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4
    UniProtKB/TrEMBL
    D6RB01

  5. NM_001376053.1 → NP_001362982.1  soluble lamin-associated protein of 75 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214
    UniProtKB/TrEMBL
    D6RB01

  6. NM_001376054.1 → NP_001362983.1  soluble lamin-associated protein of 75 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214

  7. NM_015566.3 → NP_056381.1  soluble lamin-associated protein of 75 kDa isoform 1

    See identical proteins and their annotated locations for NP_056381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.
    Source sequence(s)
    AB020695, AC010501, AC093214, DA326879
    Consensus CDS
    CCDS43330.1
    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4
    UniProtKB/TrEMBL
    D6RB01
    Related
    ENSP00000373808.4, ENST00000389156.9

RNA

  1. NR_046462.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 5'-most exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093214, AK022981, BX640902, DB024270
    Related
    ENST00000510609.5

  2. NR_164753.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214

  3. NR_164754.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010501, AC093214

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    74777574..74866966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417083.1 → XP_047273039.1  soluble lamin-associated protein of 75 kDa isoform X1

  2. XM_047417085.1 → XP_047273041.1  soluble lamin-associated protein of 75 kDa isoform X2

    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4

  3. XM_047417086.1 → XP_047273042.1  soluble lamin-associated protein of 75 kDa isoform X2

    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4

  4. XM_047417084.1 → XP_047273040.1  soluble lamin-associated protein of 75 kDa isoform X2

    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4

  5. XM_047417087.1 → XP_047273043.1  soluble lamin-associated protein of 75 kDa isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    75258467..75347878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352333.1 → XP_054208308.1  soluble lamin-associated protein of 75 kDa isoform X1

  2. XM_054352335.1 → XP_054208310.1  soluble lamin-associated protein of 75 kDa isoform X2

    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4

  3. XM_054352336.1 → XP_054208311.1  soluble lamin-associated protein of 75 kDa isoform X2

    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4

  4. XM_054352334.1 → XP_054208309.1  soluble lamin-associated protein of 75 kDa isoform X2

    UniProtKB/Swiss-Prot
    A8K1T9, Q6MZT0, Q9H989, Q9Y6X4

  5. XM_054352337.1 → XP_054208312.1  soluble lamin-associated protein of 75 kDa isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6X4.2 GenPept UniProtKB/Swiss-Prot:Q9Y6X4

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