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FBXO6 F-box protein 6 [ Homo sapiens (human) ]

Gene ID: 26270, updated on 10-Dec-2024

Summary

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Official Symbol
FBXO6provided by HGNC
Official Full Name
F-box protein 6provided by HGNC
Primary source
HGNC:HGNC:13585
See related
Ensembl:ENSG00000116663 MIM:605647; AllianceGenome:HGNC:13585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBG2; FBS2; FBX6; Fbx6b
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See FBXO6 in Genome Data Viewer
Location:
1p36.22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11664200..11674354)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11208255..11218422)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11724257..11734411)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11709789-11710497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11710498-11711205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 267 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:11718034-11719233 Neighboring gene F-box protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 168 Neighboring gene F-box protein 44 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11743170-11743751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11744701-11745201 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750065-11750574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750575-11751082 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11764337-11764964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11786269-11787256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808242-11808918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808919-11809595 Neighboring gene angiotensin II receptor associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation. Du K, et al. J Toxicol Sci, 2014. PMID 25374377
  2. SPPS: a sequence-based method for predicting probability of protein-protein interaction partners. Liu X, et al. PLoS One, 2012. PMID 22292078, Free PMC Article
  3. Structural basis of sugar recognition by SCF(FBS2) ubiquitin ligase involved in NGLY1 deficiency. Satoh T, et al. FEBS Lett, 2024 Sep. PMID 39171510
  4. The USP18-FBXO6 axis maintains the malignancy of ovarian cancer. Li G, et al. Biochem Biophys Res Commun, 2022 Feb 19. PMID 35063764
  5. Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer. Cai L, et al. FEBS Lett, 2019 Jul. PMID 31140586

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of sugar recognition by SCF[FBS2] ubiquitin ligase involved in NGLY1 deficiency.
    Title: Structural basis of sugar recognition by SCF(FBS2) ubiquitin ligase involved in NGLY1 deficiency.
  2. The USP18-FBXO6 axis maintains the malignancy of ovarian cancer.
    Title: The USP18-FBXO6 axis maintains the malignancy of ovarian cancer.
  3. FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
    Title: FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
  4. Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer
    Title: Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.
  5. our studies have identified a general but, to our knowledge, previously unrecognized role and a novel noncanonical mechanism of FBXO6 in modulating IFN-I-mediated antiviral immune responses
    Title: Noncanonical Role of FBXO6 in Regulating Antiviral Immunity.
  6. Fbxo6 is a novel regulator of mitosis by controlling chromosome separation via interacting with the spindle checkpoint proteins Mad2 and BubR1.
    Title: Overexpression of Fbxo6 inactivates spindle checkpoint by interacting with Mad2 and BubR1.
  7. FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis.
    Title: FBXO6-Mediated Ubiquitination and Degradation of Ero1L Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis.
  8. It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation.
    Title: FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation.
  9. systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions.
    Title: Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.
  10. Two interacting proteins of human FBXO6 protein have been found using the service in the study.
    Title: SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with F-box protein 6 (FBXO6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum quality control compartment IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-box only protein 6
Names
F-box protein FBG2
F-box protein Fbx6
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018438.6 → NP_060908.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_060908.1

    Status: REVIEWED

    Source sequence(s)
    AF129536, AK314989, BC020880
    Consensus CDS
    CCDS133.1
    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72
    Related
    ENSP00000365944.4, ENST00000376753.9
    Conserved Domains (2) summary
    pfam04300
    Location:79 → 257
    FBA; F-box associated region
    pfam12937
    Location:13 → 58
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11664200..11674354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263448.6 → XP_005263505.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263505.1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72
    Conserved Domains (2) summary
    pfam04300
    Location:79 → 257
    FBA; F-box associated region
    pfam12937
    Location:13 → 58
    F-box-like

  2. XM_005263451.6 → XP_005263508.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263508.1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72
    Conserved Domains (2) summary
    pfam04300
    Location:79 → 257
    FBA; F-box associated region
    pfam12937
    Location:13 → 58
    F-box-like

  3. XM_005263449.6 → XP_005263506.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263506.1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72
    Related
    ENSP00000388781.1, ENST00000449067.1
    Conserved Domains (2) summary
    pfam04300
    Location:79 → 257
    FBA; F-box associated region
    pfam12937
    Location:13 → 58
    F-box-like

  4. XM_011541232.4 → XP_011539534.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011539534.1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72
    Conserved Domains (2) summary
    pfam04300
    Location:79 → 257
    FBA; F-box associated region
    pfam12937
    Location:13 → 58
    F-box-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    11208255..11218422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335955.1 → XP_054191930.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72

  2. XM_054335954.1 → XP_054191929.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72

  3. XM_054335957.1 → XP_054191932.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72

  4. XM_054335956.1 → XP_054191931.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    B1AK42, B2RC88, Q9NRD1, Q9UKT3
    UniProtKB/TrEMBL
    J3KQ72
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRD1.1 GenPept UniProtKB/Swiss-Prot:Q9NRD1

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