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Plekhg3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 [ Mus musculus (house mouse) ]

Gene ID: 263406, updated on 9-Dec-2024

Summary

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Official Symbol
Plekhg3provided by MGI
Official Full Name
pleckstrin homology domain containing, family G (with RhoGef domain) member 3provided by MGI
Primary source
MGI:MGI:2388284
See related
Ensembl:ENSMUSG00000052609 AllianceGenome:MGI:2388284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; choroid plexus; early embryo; respiratory system; and sensory organ. Orthologous to human PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 15.9), bladder adult (RPKM 13.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhg3 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76580330..76627265)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76533303..76580489)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7147 Neighboring gene predicted gene, 40445 Neighboring gene microRNA 5135 Neighboring gene STARR-positive B cell enhancer ABC_E7148 Neighboring gene expressed sequence AI463170 Neighboring gene STARR-seq mESC enhancer starr_32529 Neighboring gene STARR-seq mESC enhancer starr_32530 Neighboring gene STARR-positive B cell enhancer ABC_E8490 Neighboring gene spectrin beta, erythrocytic Neighboring gene STARR-seq mESC enhancer starr_32532 Neighboring gene STARR-seq mESC enhancer starr_32533 Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Nguyen TT, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27555588, Free PMC Article
  2. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
  3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
    Title: PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40768

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family G member 3
Names
PH domain-containing family G member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403197.1 → NP_001390126.1  pleckstrin homology domain-containing family G member 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163033
    Related
    ENSMUSP00000151851.2, ENSMUST00000219063.2

  2. NM_001403198.1 → NP_001390127.1  pleckstrin homology domain-containing family G member 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163033

  3. NM_153804.5 → NP_722499.4  pleckstrin homology domain-containing family G member 3 isoform 2

    See identical proteins and their annotated locations for NP_722499.4

    Status: VALIDATED

    Source sequence(s)
    AC163033
    Consensus CDS
    CCDS25994.1
    UniProtKB/Swiss-Prot
    E9QL46, Q3TSI8, Q4VAC9, Q6A041, Q8BJP5, Q8K0L5, Q8K0T6
    Related
    ENSMUSP00000074729.5, ENSMUST00000075249.6
    Conserved Domains (2) summary
    cd13243
    Location:253 → 396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:97 → 270
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76580330..76627265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515870.4 → XP_006515933.1  pleckstrin homology domain-containing family G member 3 isoform X2

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  2. XM_006515880.3 → XP_006515943.1  pleckstrin homology domain-containing family G member 3 isoform X10

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  3. XM_006515869.3 → XP_006515932.1  pleckstrin homology domain-containing family G member 3 isoform X1

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  4. XM_006515878.3 → XP_006515941.1  pleckstrin homology domain-containing family G member 3 isoform X9

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  5. XM_006515876.3 → XP_006515939.1  pleckstrin homology domain-containing family G member 3 isoform X7

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  6. XM_006515877.3 → XP_006515940.1  pleckstrin homology domain-containing family G member 3 isoform X8

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  7. XM_006515871.3 → XP_006515934.1  pleckstrin homology domain-containing family G member 3 isoform X3

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  8. XM_006515872.3 → XP_006515935.1  pleckstrin homology domain-containing family G member 3 isoform X4

    Conserved Domains (2) summary
    smart00325
    Location:118 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  9. XM_006515874.4 → XP_006515937.1  pleckstrin homology domain-containing family G member 3 isoform X5

    See identical proteins and their annotated locations for XP_006515937.1

    Conserved Domains (2) summary
    smart00325
    Location:97 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13243
    Location:253 → 396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VAC9.2 GenPept UniProtKB/Swiss-Prot:Q4VAC9

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