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Vnn3 vanin 3 [ Mus musculus (house mouse) ]

Gene ID: 26464, updated on 2-Nov-2024

Summary

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Official Symbol
Vnn3provided by MGI
Official Full Name
vanin 3provided by MGI
Primary source
MGI:MGI:1347055
See related
Ensembl:ENSMUSG00000020010 AllianceGenome:MGI:1347055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables pantetheine hydrolase activity. Involved in pantothenate metabolic process. Located in extracellular space. Is expressed in early conceptus and liver. Orthologous to human VNN3P (vanin 3, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 44.4), liver adult (RPKM 22.2) and 4 other tissues See more
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Genomic context

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See Vnn3 in Genome Data Viewer
Location:
10 A4; 10 11.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23727360..23745741)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23851462..23869843)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2931 Neighboring gene predicted gene, 23130 Neighboring gene ribosomal protein S12 Neighboring gene STARR-seq mESC enhancer starr_26049 Neighboring gene solute carrier family 18, subfamily B, member 1 Neighboring gene STARR-seq mESC enhancer starr_26051 Neighboring gene STARR-positive B cell enhancer ABC_E8327 Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene STARR-seq mESC enhancer starr_26055 Neighboring gene vanin 1 Neighboring gene STARR-seq mESC enhancer starr_26056 Neighboring gene trace amine-associated receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Aurrand-Lions M, et al. Immunity, 1996 Nov. PMID 8934567
  2. Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. Min-Oo G, et al. J Exp Med, 2007 Mar 19. PMID 17312006, Free PMC Article
  3. An ESTs description of the new Vanin gene family conserved from fly to human. Granjeaud S, et al. Immunogenetics, 1999 Oct. PMID 10501839
  4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Martin F, et al. Immunogenetics, 2001 May-Jun. PMID 11491533
  5. Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation. Karagianni P, et al. Cell Rep, 2020 Feb 4. PMID 32023452, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124285

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pantetheine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantetheine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in pantothenate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pantothenate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vascular non-inflammatory molecule 3
NP_036109.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011979.2 → NP_036109.3  vascular non-inflammatory molecule 3 precursor

    See identical proteins and their annotated locations for NP_036109.3

    Status: VALIDATED

    Source sequence(s)
    AC153973
    Consensus CDS
    CCDS23734.1
    UniProtKB/Swiss-Prot
    E9QMT9, Q9QZ25
    UniProtKB/TrEMBL
    Q2T9H5
    Related
    ENSMUSP00000020190.8, ENSMUST00000020190.8
    Conserved Domains (1) summary
    cd07567
    Location:26 → 329
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    23727360..23745741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ25.3 GenPept UniProtKB/Swiss-Prot:Q9QZ25

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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