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OR11A1 olfactory receptor family 11 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 26531, updated on 2-Nov-2024

Summary

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Official Symbol
OR11A1provided by HGNC
Official Full Name
olfactory receptor family 11 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:8176
See related
Ensembl:ENSG00000204694 AllianceGenome:HGNC:8176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6M1-18; OR11A2; hs6M1-18; dJ994E9.6
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See OR11A1 in Genome Data Viewer
Location:
6p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29425504..29457071, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29300160..29331729, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29393281..29424848, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 12 subfamily D member 2 Neighboring gene olfactory receptor family 12 subfamily D member 1 (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29408251-29408751 Neighboring gene uncharacterized LOC105379641 Neighboring gene olfactory receptor family 10 subfamily C member 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:29415417-29415953 Neighboring gene olfactory receptor family 2 subfamily H member 1 Neighboring gene ubiquitin D pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complex transcription and splicing of odorant receptor genes. Volz A, et al. J Biol Chem, 2003 May 30. PMID 12637542
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. Barcellos LF, et al. PLoS Genet, 2009 Oct. PMID 19851445, Free PMC Article
  3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  4. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 11A1
Names
olfactory receptor 11A2
olfactory receptor OR6-30
olfactory receptor, family 11, subfamily A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034047.2 RefSeqGene

    Range
    5000..36567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394828.1 → NP_001381757.1  olfactory receptor 11A1

    Status: VALIDATED

    Source sequence(s)
    AJ459854, AL645927
    Consensus CDS
    CCDS34363.1
    UniProtKB/Swiss-Prot
    A2BF33, A6NFQ3, B0S7T2, Q5ST16, Q9GZK7, Q9GZK8
    UniProtKB/TrEMBL
    A0A024RCH9, A0A1U9X883, A0A1U9X8A9
    Related
    ENSP00000366354.1, ENST00000377149.5
    Conserved Domains (1) summary
    cd15911
    Location:27 → 295
    7tmA_OR11A-like; olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001394829.1 → NP_001381758.1  olfactory receptor 11A1

    Status: VALIDATED

    Source sequence(s)
    AJ459855, AL645927
    Consensus CDS
    CCDS34363.1
    UniProtKB/Swiss-Prot
    A2BF33, A6NFQ3, B0S7T2, Q5ST16, Q9GZK7, Q9GZK8
    UniProtKB/TrEMBL
    A0A024RCH9, A0A1U9X883, A0A1U9X8A9
    Related
    ENSP00000366353.1, ENST00000377148.5
    Conserved Domains (1) summary
    cd15911
    Location:27 → 295
    7tmA_OR11A-like; olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_013937.4 → NP_039225.1  olfactory receptor 11A1

    See identical proteins and their annotated locations for NP_039225.1

    Status: VALIDATED

    Source sequence(s)
    AL645927
    Consensus CDS
    CCDS34363.1
    UniProtKB/Swiss-Prot
    A2BF33, A6NFQ3, B0S7T2, Q5ST16, Q9GZK7, Q9GZK8
    UniProtKB/TrEMBL
    A0A024RCH9, A0A1U9X883, A0A1U9X8A9
    Related
    ENSP00000493093.1, ENST00000641152.2
    Conserved Domains (1) summary
    cd15911
    Location:27 → 295
    7tmA_OR11A-like; olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    29425504..29457071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    691169..722731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    911953..943524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    691032..722594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    690640..722195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    690872..722445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    690974..722536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    734515..766084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    29300160..29331729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZK7.1 GenPept UniProtKB/Swiss-Prot:Q9GZK7

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