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Tafa2 TAFA chemokine like family member 2 [ Mus musculus (house mouse) ]

Gene ID: 268354, updated on 2-Nov-2024

Summary

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Official Symbol
Tafa2provided by MGI
Official Full Name
TAFA chemokine like family member 2provided by MGI
Primary source
MGI:MGI:2143691
See related
Ensembl:ENSMUSG00000044071 AllianceGenome:MGI:2143691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sam2; Tafa-2; Fam19a2; 6330575M02; FAM19A2 TAFA-2
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in CNS E18 (RPKM 7.3), whole brain E14.5 (RPKM 3.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Tafa2 in Genome Data Viewer
Location:
10 D2; 10 72.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (123099813..123577109)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (123264024..123741204)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 15 Neighboring gene predicted gene, 36628 Neighboring gene predicted gene 4129 Neighboring gene STARR-seq mESC enhancer starr_28144 Neighboring gene predicted gene, 22958 Neighboring gene predicted gene, 40794 Neighboring gene TPX2, microtubule-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_28146 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28147 Neighboring gene eukaryotic translation initiation factor 3, subunit I pseudogene Neighboring gene STARR-seq mESC enhancer starr_28148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice. Wang X, et al. Acta Biochim Biophys Sin (Shanghai), 2018 Oct 1. PMID 30137205, Free PMC Article
  2. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway. Liang H, et al. Life Sci, 2023 Dec 1. PMID 37944639
  3. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Tom Tang Y, et al. Genomics, 2004 Apr. PMID 15028294
  4. Molecular logic of cellular diversification in the mouse cerebral cortex. Di Bella DJ, et al. Nature, 2021 Jul. PMID 34163074, Free PMC Article
  5. Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex. Munz M, et al. Cell, 2023 Apr 27. PMID 37071993, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
    Title: Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
  2. chemokine-like protein TAFA-2
    Title: Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemokine-like protein TAFA-2
Names
family with sequence similarity 19, member A2
protein FAM19A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252387.1 → NP_001239316.1  chemokine-like protein TAFA-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239316.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK140763, AK164201, BC027082, CD350359
    Consensus CDS
    CCDS88096.1
    UniProtKB/Swiss-Prot
    Q5M9Q3, Q7TPG7
    Related
    ENSMUSP00000159016.2, ENSMUST00000238972.2
    Conserved Domains (1) summary
    pfam12020
    Location:41 → 129
    TAFA; TAFA family

  2. NM_182807.3 → NP_877959.2  chemokine-like protein TAFA-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_877959.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK140763, BC027082, CD350359
    Consensus CDS
    CCDS48709.1
    UniProtKB/TrEMBL
    A0A0R4J0M7
    Related
    ENSMUSP00000050199.8, ENSMUST00000050756.8
    Conserved Domains (1) summary
    pfam12020
    Location:45 → 133
    TAFA; TAFA family

RNA

  1. NR_045514.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' region and includes an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK139403, AK140763, BC027082, CD350359
    Related
    ENSMUST00000218926.2

  2. NR_153334.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AK140763, BC027082, CD350359

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    123099813..123577109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313953.3 → XP_017169442.1  chemokine-like protein TAFA-2 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:80 → 167
    TAFA; TAFA family

  2. XM_017313952.3 → XP_017169441.1  chemokine-like protein TAFA-2 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:80 → 168
    TAFA; TAFA family

  3. XM_036155793.1 → XP_036011686.1  chemokine-like protein TAFA-2 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:80 → 167
    TAFA; TAFA family

  4. XM_036155794.1 → XP_036011687.1  chemokine-like protein TAFA-2 isoform X4

    Conserved Domains (1) summary
    pfam12020
    Location:45 → 132
    TAFA; TAFA family

  5. XM_030245097.2 → XP_030100957.1  chemokine-like protein TAFA-2 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J0M7
    Conserved Domains (1) summary
    pfam12020
    Location:45 → 133
    TAFA; TAFA family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPG7.1 GenPept UniProtKB/Swiss-Prot:Q7TPG7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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