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Golga3 golgin A3 [ Mus musculus (house mouse) ]

Gene ID: 269682, updated on 9-Aug-2024

Summary

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Official Symbol
Golga3provided by MGI
Official Full Name
golgin A3provided by MGI
Primary source
MGI:MGI:96958
See related
Ensembl:ENSMUSG00000029502 AllianceGenome:MGI:96958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mea2; Mea-2; repro27; G1-499-14; 5330413L04; Mea2/Golga3; 5430416E01Rik
Summary
Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in Golgi membrane and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; gut; and nervous system. Orthologous to human GOLGA3 (golgin A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.9), bladder adult (RPKM 5.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Golga3 in Genome Data Viewer
Location:
5 F; 5 53.36 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110324723..110374336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110176857..110226470)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene STARR-positive B cell enhancer mm9_chr5:110605377-110605678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:110605669-110605852 Neighboring gene predicted gene 15787 Neighboring gene uncharacterized LOC118568795 Neighboring gene STARR-seq mESC enhancer starr_13947 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13949 Neighboring gene phosphoglycerate mutase family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis. Xu C, et al. PeerJ, 2023. PMID 37090114, Free PMC Article
  2. New point mutation in Golga3 causes multiple defects in spermatogenesis. Bentson LF, et al. Andrology, 2013 May. PMID 23495255, Free PMC Article
  3. Mea2/Golga3 gene is disrupted in a line of transgenic mice with a reciprocal translocation between Chromosomes 5 and 19 and is responsible for a defective spermatogenesis in homozygotes. Matsukuma S, et al. Mamm Genome, 1999 Jan. PMID 9892724
  4. Cloning and molecular characterization of cDNA encoding a mouse male-enhanced antigen-2 (Mea-2): a putative family of the Golgi autoantigen. Kondo M, et al. DNA Seq, 1997. PMID 9063644
  5. Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes. Williams D, et al. Mol Biol Cell, 2006 Dec. PMID 17050738, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis.
    Title: Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis.
  2. Golga3(repro27) mice lack GOLGA3 protein and thus provide an in vivo tool to aid in deciphering the role of GOLGA3 in Golgi complex positioning, cargo trafficking and apoptosis signalling in male germ cells
    Title: New point mutation in Golga3 causes multiple defects in spermatogenesis.
  3. These data demonstrate that golgin-160 plays an important role in directing insulin-regulated trafficking proteins toward the insulin-responsive compartment in adipocytes.
    Title: Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes.
  4. a truncated form of Mea2 devoid of the N-terminal region, DeltaMea2, was expressed
    Title: Co-localization of Trax and Mea2 in Golgi complex of pachytene spermatocytes in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (2) 
  • Transgenic (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
golgin subfamily A member 3
Names
golgi autoantigen, golgin subfamily a, 3
golgin-160
male-enhanced antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347389.2 → NP_001334318.1  golgin subfamily A member 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118260
    Consensus CDS
    CCDS84928.1
    UniProtKB/Swiss-Prot
    P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
    UniProtKB/TrEMBL
    E9QP99
    Related
    ENSMUSP00000031477.9, ENSMUST00000031477.9
    Conserved Domains (2) summary
    COG1196
    Location:622 → 1357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:431 → 771
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_008146.4 → NP_032172.3  golgin subfamily A member 3 isoform 2

    See identical proteins and their annotated locations for NP_032172.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC118260, AW490576, BC053002
    Consensus CDS
    CCDS39209.1
    UniProtKB/Swiss-Prot
    P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
    UniProtKB/TrEMBL
    A0A0R4J1H6
    Related
    ENSMUSP00000108131.2, ENSMUST00000112512.8
    Conserved Domains (2) summary
    COG1196
    Location:582 → 1317
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:353 → 724
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110324723..110374336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534961.5 → XP_006535024.1  golgin subfamily A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006535024.1

    UniProtKB/Swiss-Prot
    P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
    UniProtKB/TrEMBL
    E9QP99
    Conserved Domains (2) summary
    COG1196
    Location:622 → 1357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:431 → 771
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_030254534.2 → XP_030110394.1  golgin subfamily A member 3 isoform X2

    UniProtKB/Swiss-Prot
    P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
    UniProtKB/TrEMBL
    A0A0R4J1H6
    Conserved Domains (2) summary
    COG1196
    Location:582 → 1317
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:353 → 724
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006534962.4 → XP_006535025.1  golgin subfamily A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006535025.1

    UniProtKB/Swiss-Prot
    P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
    UniProtKB/TrEMBL
    E9QP99
    Conserved Domains (2) summary
    COG1196
    Location:622 → 1357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:431 → 771
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55937.3 GenPept UniProtKB/Swiss-Prot:P55937

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