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Cntn4 contactin 4 [ Mus musculus (house mouse) ]

Gene ID: 269784, updated on 17-Aug-2024

Summary

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Official Symbol
Cntn4provided by MGI
Official Full Name
contactin 4provided by MGI
Primary source
MGI:MGI:1095737
See related
Ensembl:ENSMUSG00000064293 AllianceGenome:MGI:1095737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Axcam; BIG-2; 9630050B05
Summary
Predicted to be involved in negative regulation of neuron differentiation and neuron projection development. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region and plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in neuron projection. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human CNTN4 (contactin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.4), cortex adult (RPKM 2.4) and 6 other tissues See more
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Genomic context

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See Cntn4 in Genome Data Viewer
Location:
6 E1; 6 48.93 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (105654505..106677102)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (105677632..106700141)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16929 Neighboring gene STARR-seq mESC enhancer starr_16930 Neighboring gene predicted gene, 19757 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene predicted gene 15631 Neighboring gene STARR-seq mESC enhancer starr_16931 Neighboring gene STARR-seq mESC enhancer starr_16932 Neighboring gene STARR-seq mESC enhancer starr_16934 Neighboring gene STARR-seq mESC enhancer starr_16935 Neighboring gene STARR-seq mESC enhancer starr_16936 Neighboring gene STARR-positive B cell enhancer ABC_E6462 Neighboring gene STARR-positive B cell enhancer ABC_E4850 Neighboring gene STARR-positive B cell enhancer ABC_E9278 Neighboring gene STARR-seq mESC enhancer starr_16937 Neighboring gene STARR-positive B cell enhancer ABC_E3665 Neighboring gene interleukin 5 receptor, alpha Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 Neighboring gene cereblon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The autism risk gene CNTN4 modulates dendritic spine formation. Zhao R, et al. Hum Mol Genet, 2021 Dec 27. PMID 34415325
  2. Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice. Molenhuis RT, et al. J Neurodev Disord, 2016. PMID 26958094, Free PMC Article
  3. Functional organization of the promoter region of the mouse F3 axonal glycoprotein gene. Cangiano G, et al. Brain Res Mol Brain Res, 1997 Sep. PMID 9332725
  4. BIG-2 mediates olfactory axon convergence to target glomeruli. Kaneko-Goto T, et al. Neuron, 2008 Mar 27. PMID 18367085
  5. A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Mimmack ML, et al. Brain Res Mol Brain Res, 1997 Jul. PMID 9221934

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNTN4 modulates neural elongation through interplay with APP.
    Title: CNTN4 modulates neural elongation through interplay with APP.
  2. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
    Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
  3. including the adhesion molecule CNTN4,which contributed to the enhanced response
    Title: Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.
  4. These results suggest that BIG-2 is one of the axon guidance molecules crucial for the formation and maintenance of functional odor map in the olfactory bulb.
    Title: BIG-2 mediates olfactory axon convergence to target glomeruli.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
contactin-4
Names
axonal-associated cell adhesion molecule
brain-derived immunoglobulin superfamily molecule
brain-derived immunoglobulin superfamily protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109749.2 → NP_001103219.1  contactin-4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, and 6-9 all encode the same isoform (1).
    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
    Consensus CDS
    CCDS51866.1
    UniProtKB/Swiss-Prot
    Q14BL8, Q69Z26, Q8BRT6, Q8CBD3
    Related
    ENSMUSP00000108889.3, ENSMUST00000113264.9
    Conserved Domains (3) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  2. NM_001109751.2 → NP_001103221.1  contactin-4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001103221.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), also known as BIG-2A, uses alternate 5' and 3' exons, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    Consensus CDS
    CCDS20395.1
    UniProtKB/TrEMBL
    F8WH58
    Conserved Domains (4) summary
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:27 → 31
    Ig; Ig strand A [structural motif]
    cd05853
    Location:496 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cl11960
    Location:25 → 120
    Ig; Immunoglobulin domain

  3. NM_001364565.2 → NP_001351494.1  contactin-4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    Consensus CDS
    CCDS51866.1
    UniProtKB/Swiss-Prot
    Q14BL8, Q69Z26, Q8BRT6, Q8CBD3
    Conserved Domains (3) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  4. NM_001364566.2 → NP_001351495.1  contactin-4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
    Conserved Domains (3) summary
    cd00063
    Location:596 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:496 → 502
    Ig; Ig strand A [structural motif]
    cl11960
    Location:496 → 596
    Ig; Immunoglobulin domain

  5. NM_001411717.1 → NP_001398646.1  contactin-4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    UniProtKB/Swiss-Prot
    Q14BL8, Q69Z26, Q8BRT6, Q8CBD3

  6. NM_001411718.1 → NP_001398647.1  contactin-4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
    UniProtKB/Swiss-Prot
    Q14BL8, Q69Z26, Q8BRT6, Q8CBD3
    Related
    ENSMUSP00000086616.3, ENSMUST00000089208.9

  7. NM_001411719.1 → NP_001398648.1  contactin-4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    UniProtKB/Swiss-Prot
    Q14BL8, Q69Z26, Q8BRT6, Q8CBD3

  8. NM_001411720.1 → NP_001398649.1  contactin-4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    UniProtKB/Swiss-Prot
    Q14BL8, Q69Z26, Q8BRT6, Q8CBD3

  9. NM_001411721.1 → NP_001398650.1  contactin-4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  10. NM_001411722.1 → NP_001398651.1  contactin-4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  11. NM_001411723.1 → NP_001398652.1  contactin-4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  12. NM_001411724.1 → NP_001398653.1  contactin-4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  13. NM_001411725.1 → NP_001398654.1  contactin-4 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  14. NM_001411726.1 → NP_001398655.1  contactin-4 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  15. NM_001411727.1 → NP_001398656.1  contactin-4 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  16. NM_001411728.1 → NP_001398657.1  contactin-4 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  17. NM_001411729.1 → NP_001398658.1  contactin-4 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  18. NM_001411730.1 → NP_001398659.1  contactin-4 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  19. NM_001411731.1 → NP_001398660.1  contactin-4 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  20. NM_001411732.1 → NP_001398661.1  contactin-4 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  21. NM_001411733.1 → NP_001398662.1  contactin-4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    UniProtKB/TrEMBL
    F8WH58

  22. NM_001411734.1 → NP_001398663.1  contactin-4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169
    UniProtKB/TrEMBL
    F8WH58
    Related
    ENSMUSP00000108885.2, ENSMUST00000113260.8

  23. NM_001411735.1 → NP_001398664.1  contactin-4 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
    UniProtKB/TrEMBL
    F8WH58

  24. NM_001411736.1 → NP_001398665.1  contactin-4 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
    UniProtKB/TrEMBL
    F8WH58

  25. NM_173004.4 → NP_766592.2  contactin-4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_766592.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter and distinct C-terminus compared to isoform 1. Variants 2, 3, 22, and 23 all encode the same isoform (2).
    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
    Consensus CDS
    CCDS20395.1
    UniProtKB/TrEMBL
    F8WH58
    Related
    ENSMUSP00000108886.3, ENSMUST00000113261.9
    Conserved Domains (4) summary
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:27 → 31
    Ig; Ig strand A [structural motif]
    cd05853
    Location:496 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cl11960
    Location:25 → 120
    Ig; Immunoglobulin domain

RNA

  1. NR_177642.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  2. NR_177643.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  3. NR_177644.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

  4. NR_177645.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  5. NR_177646.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  6. NR_177647.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  7. NR_177648.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  8. NR_177649.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  9. NR_177650.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

  10. NR_177651.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153988, AC153991, AC156281, AC159546, AC164169

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    105654505..106677102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166177.1 → XP_036022070.1  contactin-4 isoform X5

    UniProtKB/TrEMBL
    F8WH58
    Conserved Domains (4) summary
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:27 → 31
    Ig; Ig strand A [structural motif]
    cd05853
    Location:496 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cl11960
    Location:25 → 120
    Ig; Immunoglobulin domain

  2. XM_036166179.1 → XP_036022072.1  contactin-4 isoform X6

    UniProtKB/TrEMBL
    F8WH58
    Conserved Domains (3) summary
    cd00063
    Location:596 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:496 → 502
    Ig; Ig strand A [structural motif]
    cl11960
    Location:496 → 596
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69Z26.2 GenPept UniProtKB/Swiss-Prot:Q69Z26

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