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Myo9a myosin IXa [ Mus musculus (house mouse) ]

Gene ID: 270163, updated on 14-Nov-2024

Summary

Official Symbol
Myo9aprovided by MGI
Official Full Name
myosin IXaprovided by MGI
Primary source
MGI:MGI:107735
See related
Ensembl:ENSMUSG00000039585 AllianceGenome:MGI:107735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230003M11; 4732465J09Rik; C130068I12Rik
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in postsynaptic specialization organization and regulation of neuron projection arborization. Located in axonal growth cone. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study focal segmental glomerulosclerosis and obstructive hydrocephalus. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 7.1), whole brain E14.5 (RPKM 5.5) and 21 other tissues See more
Orthologs
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Genomic context

See Myo9a in Genome Data Viewer
Location:
9 B; 9 32.13 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59658128..59836149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59750848..59928866)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:59570886-59571186 Neighboring gene GRAM domain containing 2A Neighboring gene STARR-positive B cell enhancer mm9_chr9:59598396-59598697 Neighboring gene transcription factor BTF3-like Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene STARR-seq mESC enhancer starr_24313 Neighboring gene predicted gene, 20275 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24314 Neighboring gene predicted gene 7616 Neighboring gene nuclear receptor subfamily 2, group E, member 3 Neighboring gene thrombospondin, type I, domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_24316 Neighboring gene STARR-seq mESC enhancer starr_24317 Neighboring gene STARR-seq mESC enhancer starr_24318 Neighboring gene STARR-seq mESC enhancer starr_24319 Neighboring gene RIKEN cDNA 2010001M07 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
unconventional myosin-IXa
Names
unconventional myosin-9a

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173018.2NP_766606.2  unconventional myosin-IXa

    Status: VALIDATED

    Source sequence(s)
    AC131749, AC156795, AC160637
    Consensus CDS
    CCDS52820.1
    UniProtKB/TrEMBL
    D3Z3A8
    Related
    ENSMUSP00000122852.2, ENSMUST00000136740.8
    Conserved Domains (5) summary
    smart00015
    Location:11161137
    IQ; Calmodulin-binding motif
    cd04377
    Location:21342319
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601005
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    cd20883
    Location:20682125
    C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    59658128..59836149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155030.1XP_036010923.1  unconventional myosin-IXa isoform X2

    Conserved Domains (5) summary
    smart00015
    Location:11161137
    IQ; Calmodulin-binding motif
    cd04377
    Location:21352320
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601005
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    cd20883
    Location:20692126
    C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
  2. XM_036155031.1XP_036010924.1  unconventional myosin-IXa isoform X4

    UniProtKB/TrEMBL
    D3Z3A8
    Conserved Domains (5) summary
    smart00015
    Location:11161137
    IQ; Calmodulin-binding motif
    cd04377
    Location:21342319
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601005
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    cd20883
    Location:20682125
    C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
  3. XM_006511209.5XP_006511272.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_006511272.1

    Conserved Domains (7) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd00029
    Location:20752123
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21362321
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:18271891
    PEHE; PEHE domain
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)
  4. XM_006511210.3XP_006511273.1  unconventional myosin-IXa isoform X2

    Conserved Domains (5) summary
    smart00015
    Location:11161137
    IQ; Calmodulin-binding motif
    cd04377
    Location:21352320
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601005
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    cd20883
    Location:20692126
    C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
  5. XM_017313399.2XP_017168888.1  unconventional myosin-IXa isoform X11

    Conserved Domains (7) summary
    smart00015
    Location:11161137
    IQ; Calmodulin-binding motif
    cd00029
    Location:20022050
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20632248
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601005
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:17541818
    PEHE; PEHE domain
    pfam17380
    Location:9671282
    DUF5401; Family of unknown function (DUF5401)
  6. XM_006511220.3XP_006511283.1  unconventional myosin-IXa isoform X14

    See identical proteins and their annotated locations for XP_006511283.1

    UniProtKB/Swiss-Prot
    Q3TRT5, Q4VBD3, Q80Y92, Q8C0U0, Q8C170
    Related
    ENSMUSP00000119401.2, ENSMUST00000128341.2
    Conserved Domains (7) summary
    smart00015
    Location:11161137
    IQ; Calmodulin-binding motif
    cd00029
    Location:20022050
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20632248
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601005
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:17541818
    PEHE; PEHE domain
    pfam17380
    Location:9671282
    DUF5401; Family of unknown function (DUF5401)
  7. XM_036155033.1XP_036010926.1  unconventional myosin-IXa isoform X9

    Conserved Domains (5) summary
    smart00015
    Location:10971118
    IQ; Calmodulin-binding motif
    cd04377
    Location:21152300
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:160986
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    cd20883
    Location:20492106
    C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
  8. XM_006511215.4XP_006511278.1  unconventional myosin-IXa isoform X8

    Conserved Domains (7) summary
    smart00015
    Location:10971118
    IQ; Calmodulin-binding motif
    cd00029
    Location:20552103
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21162301
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:160986
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:18071871
    PEHE; PEHE domain
    pfam17380
    Location:9481263
    DUF5401; Family of unknown function (DUF5401)
  9. XM_006511208.4XP_006511271.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_006511271.1

    Conserved Domains (7) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd00029
    Location:20752123
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21362321
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:18271891
    PEHE; PEHE domain
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)
  10. XM_006511212.4XP_006511275.1  unconventional myosin-IXa isoform X5

    Conserved Domains (7) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd00029
    Location:20752123
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21362321
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:18271891
    PEHE; PEHE domain
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)
  11. XM_006511211.4XP_006511274.1  unconventional myosin-IXa isoform X3

    Conserved Domains (7) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd00029
    Location:20742122
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21352320
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:18261890
    PEHE; PEHE domain
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)
  12. XM_036155032.1XP_036010925.1  unconventional myosin-IXa isoform X6

    Related
    ENSMUSP00000117432.2, ENSMUST00000135298.8
    Conserved Domains (5) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd04377
    Location:21352320
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    cd20883
    Location:20692126
    C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
  13. XM_006511216.4XP_006511279.1  unconventional myosin-IXa isoform X10

    Conserved Domains (7) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd00029
    Location:20032051
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20642249
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:17551819
    PEHE; PEHE domain
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)
  14. XM_006511217.4XP_006511280.1  unconventional myosin-IXa isoform X12

    Conserved Domains (7) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd00029
    Location:20032051
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20642249
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:17551819
    PEHE; PEHE domain
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)
  15. XM_006511213.4XP_006511276.1  unconventional myosin-IXa isoform X7

    Conserved Domains (7) summary
    smart00015
    Location:10981119
    IQ; Calmodulin-binding motif
    cd00029
    Location:20562104
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21172302
    RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
    cd01385
    Location:160987
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam15275
    Location:18081872
    PEHE; PEHE domain
    pfam17380
    Location:9491264
    DUF5401; Family of unknown function (DUF5401)
  16. XM_017313400.3XP_017168889.1  unconventional myosin-IXa isoform X13

    Conserved Domains (4) summary
    smart00015
    Location:11171138
    IQ; Calmodulin-binding motif
    cd01385
    Location:1601006
    MYSc_Myo9; class IX myosin, motor domain
    cd17216
    Location:15110
    RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
    pfam17380
    Location:9681283
    DUF5401; Family of unknown function (DUF5401)