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Gyg1 glycogenin 1 [ Mus musculus (house mouse) ]

Gene ID: 27357, updated on 14-Nov-2024

Summary

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Official Symbol
Gyg1provided by MGI
Official Full Name
glycogenin 1provided by MGI
Primary source
MGI:MGI:1351614
See related
Ensembl:ENSMUSG00000019528 AllianceGenome:MGI:1351614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GN1; Gyg
Summary
Enables glycogenin glucosyltransferase activity. Involved in glycogen biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and respiratory system. Used to study glycogen storage disease XV. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to human GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 43.0), lung adult (RPKM 28.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Gyg1 in Genome Data Viewer
Location:
3 A2; 3 6.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (20176248..20209228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (20122083..20155117, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ceruloplasmin Neighboring gene STARR-seq mESC enhancer starr_07104 Neighboring gene STARR-seq mESC enhancer starr_07105 Neighboring gene HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E3428 Neighboring gene STARR-seq mESC enhancer starr_07106 Neighboring gene STARR-seq mESC enhancer starr_07107 Neighboring gene STARR-positive B cell enhancer ABC_E1018 Neighboring gene helicase-like transcription factor Neighboring gene STARR-seq mESC enhancer starr_07108 Neighboring gene VISTA enhancer mm86 Neighboring gene STARR-seq mESC enhancer starr_07112 Neighboring gene STARR-seq mESC enhancer starr_07113 Neighboring gene predicted gene, 31320 Neighboring gene microRNA 7007 Neighboring gene carboxypeptidase A3, mast cell Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular analysis of skewed Tcra-V gene use in T-cell receptor beta-chain transgenic mice. Burns RP Jr, et al. Immunogenetics, 1998. PMID 9396856
  2. Characterization of mouse glycogenin-1 cDNA and promoter region. van Maanen M, et al. Biochim Biophys Acta, 1999 Oct 28. PMID 10542328
  3. Glycogenin, proglycogen, and glycogen biogenesis: what's the story? Katz A. Am J Physiol Endocrinol Metab, 2006 Apr. PMID 16533952
  4. Modulation of glycogen synthesis by RNA interference: towards a new therapeutic approach for glycogenosis type II. Douillard-Guilloux G, et al. Hum Mol Genet, 2008 Dec 15. PMID 18782850
  5. Getting a handle on glycogen synthase - Its interaction with glycogenin. Zeqiraj E, et al. Mol Aspects Med, 2015 Dec. PMID 26278983, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome.
    Title: Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome.
  2. Glycogenin depletion causes high glycogen accumulation in striated muscles. Glycogenin depletion alters skeletal muscle functionality. Over - accumulation of skeletal muscle glycogen affects oxidative metabolism.
    Title: Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment.
  3. Injection of recombinant adeno-associated virus-1 vector expressing glycogen synthase short hairpin ribonucleic acids into mice with type II glycogen storage disease leads to significant reduction in impaired glycogen accumulation.
    Title: Modulation of glycogen synthesis by RNA interference: towards a new therapeutic approach for glycogenosis type II.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose binding ISO
Inferred from Sequence Orthology
more info
  
enables glycogenin glucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycogenin glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycogenin glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycogenin-1
Names
glycogenin
NP_001342190.1
NP_001398101.1
NP_001398102.1
NP_001398103.1
NP_001398104.1
NP_001398105.1
NP_038783.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355261.2 → NP_001342190.1  glycogenin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158937
    UniProtKB/TrEMBL
    V9GX26
    Related
    ENSMUSP00000138949.2, ENSMUST00000184552.2
    Conserved Domains (1) summary
    cd02537
    Location:4 → 254
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen

  2. NM_001411172.1 → NP_001398101.1  glycogenin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158937

  3. NM_001411173.1 → NP_001398102.1  glycogenin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158937

  4. NM_001411174.1 → NP_001398103.1  glycogenin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158937

  5. NM_001411175.1 → NP_001398104.1  glycogenin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158937

  6. NM_001411176.1 → NP_001398105.1  glycogenin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158937

  7. NM_013755.5 → NP_038783.1  glycogenin-1 isoform 2

    See identical proteins and their annotated locations for NP_038783.1

    Status: VALIDATED

    Source sequence(s)
    AC158937
    Consensus CDS
    CCDS50873.1
    UniProtKB/Swiss-Prot
    Q3TWR9, Q9R062
    UniProtKB/TrEMBL
    V9GX26
    Related
    ENSMUSP00000136035.2, ENSMUST00000178328.8
    Conserved Domains (2) summary
    cd02537
    Location:4 → 254
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:92 → 221
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    20176248..20209228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R062.3 GenPept UniProtKB/Swiss-Prot:Q9R062

Gene LinkOut

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