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Nagpa N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [ Mus musculus (house mouse) ]

Gene ID: 27426, updated on 9-Dec-2024

Summary

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Official Symbol
Nagpaprovided by MGI
Official Full Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidaseprovided by MGI
Primary source
MGI:MGI:1351598
See related
Ensembl:ENSMUSG00000023143 AllianceGenome:MGI:1351598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCE
Summary
Predicted to enable N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity. Acts upstream of or within secretion of lysosomal enzymes. Predicted to be located in Golgi cisterna membrane. Is expressed in thymus primordium. Orthologous to human NAGPA (N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 27.5), ovary adult (RPKM 22.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nagpa in Genome Data Viewer
Location:
16 A1; 16 2.51 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (5013144..5024891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5195280..5204032, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 126A pseudogene Neighboring gene periplakin Neighboring gene SEC14-like lipid binding 5 Neighboring gene expressed sequence AU021092 Neighboring gene microRNA 6364 Neighboring gene STARR-positive B cell enhancer mm9_chr16:5233472-5233773 Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos. Pantaleon M, et al. Biol Reprod, 2010 Apr. PMID 20032283, Free PMC Article
  2. Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. Kornfeld R, et al. J Biol Chem, 1999 Nov 12. PMID 10551838
  3. Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Boonen M, et al. Mol Biol Cell, 2009 Oct. PMID 19710420, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UCE -/- mice were viable, grew normally & lacked detectable histologic abnormalities, but plasma levels of 6 acid hydrolases were elevated. UCE accounts for all the uncovering activity in the Golgi.
    Title: Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in secretion of lysosomal enzymes IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within secretion of lysosomal enzymes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Names
alpha-GlcNAcase
mannose 6-phosphate-uncovering enzyme
phosphodiester alpha-GlcNAcase
NP_038824.2
XP_006522279.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013796.3 → NP_038824.2  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor

    See identical proteins and their annotated locations for NP_038824.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
    Source sequence(s)
    AC124576, AK032158, AK138035
    Consensus CDS
    CCDS27933.1
    UniProtKB/Swiss-Prot
    Q3UUT5, Q8BJ48, Q8CHQ8, Q9QZE6
    UniProtKB/TrEMBL
    Q3TWM3
    Related
    ENSMUSP00000023911.5, ENSMUST00000023911.11
    Conserved Domains (1) summary
    pfam09992
    Location:131 → 326
    DUF2233; Predicted periplasmic protein (DUF2233)

RNA

  1. NR_027804.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124576, AK087468, AK138035, AK168830
    Related
    ENSMUST00000147567.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    5013144..5024891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522216.5 → XP_006522279.1  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1

    UniProtKB/TrEMBL
    Q3TWM3
    Conserved Domains (1) summary
    pfam09992
    Location:131 → 326
    NAGPA; Phosphodiester glycosidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ48.2 GenPept UniProtKB/Swiss-Prot:Q8BJ48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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