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Sdic2 Sperm-specific dynein intermediate chain 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768883, updated on 26-Apr-2024

Summary

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Official Symbol
Sdic2provided by FlyBase
Official Full Name
Sperm-specific dynein intermediate chain 2provided by FlyBase
Primary source
FLYBASE:FBgn0053497
Locus tag
Dmel_CG33497
See related
AllianceGenome:FB:FBgn0053497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33497; Dmel\CG33497; Sdic; Sdic:CG33497
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Sdic2 in Genome Data Viewer
Location:
19C1-19C1; 1-64 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20181590..20186487, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20075612..20080509, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Sperm-specific dynein intermediate chain 1 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Sperm-specific dynein intermediate chain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A species-specific multigene family mediates differential sperm displacement in Drosophila melanogaster. Jayaswal V, et al. Evolution, 2018 Feb. PMID 29315521
  2. Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition. Yeh SD, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22308475, Free PMC Article
  3. Understanding the Early Evolutionary Stages of a Tandem Drosophilamelanogaster-Specific Gene Family: A Structural and Functional Population Study. Clifton BD, et al. Mol Biol Evol, 2020 Sep 1. PMID 32359138, Free PMC Article
  4. The recent origin of the Sdic gene cluster in the melanogaster subgroup. Ponce R. Genetica, 2009 Apr. PMID 18587654
  5. The use of a non-LTR element to date the formation of the Sdic gene cluster. Ponce R. Genetica, 2007 Nov. PMID 17351817

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Sperm-specific dynein intermediate chain 2
Names
CG33497-PA
CG33497-PB
CG33497-PC
Sdic2-PA
Sdic2-PB
Sdic2-PC
Sdic:CG33497

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20181590..20186487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298552.2 → NP_001285481.1  Sperm-specific dynein intermediate chain 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285481.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBX8, Q7KWG3
    Conserved Domains (5) summary
    COG2319
    Location:224 → 523
    WD40; WD40 repeat [General function prediction only]
    COG2811
    Location:108 → 178
    NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]
    pfam11540
    Location:23 → 51
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:196 → 245
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:196 → 512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001298551.2 → NP_001285480.1  Sperm-specific dynein intermediate chain 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285480.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBX8, X2JCQ7
    Conserved Domains (5) summary
    COG2319
    Location:216 → 515
    WD40; WD40 repeat [General function prediction only]
    COG2811
    Location:100 → 170
    NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]
    pfam11540
    Location:23 → 51
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:188 → 237
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:188 → 504
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_206793.2 → NP_996516.1  Sperm-specific dynein intermediate chain 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996516.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBX8, Q7KWG3
    Conserved Domains (5) summary
    COG2319
    Location:224 → 523
    WD40; WD40 repeat [General function prediction only]
    COG2811
    Location:108 → 178
    NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]
    pfam11540
    Location:23 → 51
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:196 → 245
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:196 → 512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KWG3 Q7KWG3
X2JCQ7 X2JCQ7

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