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Trim36 tripartite motif-containing 36 [ Mus musculus (house mouse) ]

Gene ID: 28105, updated on 2-Nov-2024

Summary

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Official Symbol
Trim36provided by MGI
Official Full Name
tripartite motif-containing 36provided by MGI
Primary source
MGI:MGI:106264
See related
Ensembl:ENSMUSG00000033949 AllianceGenome:MGI:106264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
haprin; D18Wsu100e
Summary
Enables alpha-tubulin binding activity and ubiquitin-protein transferase activity. Involved in regulation of cell cycle. Acts upstream of or within acrosome reaction. Located in acrosomal vesicle. Is expressed in extraembryonic component; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human TRIM36 (tripartite motif containing 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 82.8), whole brain E14.5 (RPKM 6.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Trim36 in Genome Data Viewer
Location:
18 C; 18 24.41 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46298367..46345674, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46165300..46212607, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330093E20 gene Neighboring gene STARR-seq mESC enhancer starr_44494 Neighboring gene predicted gene, 26262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:46252362-46252681 Neighboring gene STARR-positive B cell enhancer ABC_E7582 Neighboring gene predicted gene, 52355 Neighboring gene predicted gene, 51427 Neighboring gene predicted gene, 52364 Neighboring gene STARR-positive B cell enhancer ABC_E9977 Neighboring gene STARR-seq mESC enhancer starr_44498 Neighboring gene protein geranylgeranyltransferase type I, beta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Haprin-deficient spermatozoa are incapable of in vitro fertilization. Aoki Y, et al. Mol Reprod Dev, 2020 May. PMID 32311190
  2. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. Kitamura K, et al. J Biol Chem, 2003 Nov 7. PMID 12917430
  3. TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression. Miyajima N, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232519
  4. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. Short KM, et al. J Biol Chem, 2006 Mar 31. PMID 16434393
  5. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. Suzuki A, et al. J Reprod Immunol, 2024 Jun. PMID 38697008,

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Haprin-deficient spermatozoa are incapable of in vitro fertilization.
    Title: Haprin-deficient spermatozoa are incapable of in vitro fertilization.
  2. results indicated that the novel RBCC protein Haprin plays a key role in the acrosome reaction and fertilization
    Title: Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Trim36
Names
RING-type E3 ubiquitin transferase TRIM36
acrosome RBCC protein
tripartite motif-containing protein 36
NP_001164326.1
NP_849203.2
XP_036017058.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170855.1 → NP_001164326.1  E3 ubiquitin-protein ligase Trim36 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124717, BC058106, BM938922, CJ046908, CJ301781
    Consensus CDS
    CCDS50279.1
    UniProtKB/TrEMBL
    E9Q3A0
    Related
    ENSMUSP00000129771.2, ENSMUST00000167364.9
    Conserved Domains (5) summary
    smart00060
    Location:419 → 482
    FN3; Fibronectin type 3 domain
    cd00021
    Location:199 → 237
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:21 → 49
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:504 → 707
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:244 → 368
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_178872.4 → NP_849203.2  E3 ubiquitin-protein ligase Trim36 isoform 1

    See identical proteins and their annotated locations for NP_849203.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC058106, BM938922, CJ167273, CJ301781
    Consensus CDS
    CCDS29229.1
    UniProtKB/Swiss-Prot
    Q7TNM1, Q80WG7
    Related
    ENSMUSP00000037978.5, ENSMUST00000037011.6
    Conserved Domains (5) summary
    smart00060
    Location:431 → 494
    FN3; Fibronectin type 3 domain
    cd00021
    Location:211 → 249
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:33 → 61
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:516 → 719
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:256 → 380
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    46298367..46345674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161165.1 → XP_036017058.1  E3 ubiquitin-protein ligase Trim36 isoform X1

    Conserved Domains (7) summary
    smart00502
    Location:167 → 291
    BBC; B-Box C-terminal domain
    smart00060
    Location:342 → 405
    FN3; Fibronectin type 3 domain
    cd12894
    Location:427 → 630
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cd19778
    Location:121 → 165
    Bbox2_TRIM36_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    cd19848
    Location:62 → 116
    Bbox1_TRIM36_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    pfam18568
    Location:270 → 318
    COS; TRIM C-terminal subgroup One Signature domain
    cl17238
    Location:22 → 36
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WG7.2 GenPept UniProtKB/Swiss-Prot:Q80WG7

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