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PRNP prion protein [ Bos taurus (cattle) ]

Gene ID: 281427, updated on 5-Mar-2024

Summary

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Official Symbol
PRNPprovided by VGNC
Official Full Name
prion proteinprovided by VGNC
Primary source
VGNC:VGNC:33356
See related
BGD:BT10271; Ensembl:ENSBTAG00000063812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PrP; prn; AltPrP
Orthologs
human mouse all
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Genomic context

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See PRNP in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (47039937..47060168)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog C Neighboring gene small nucleolar RNA SNORD31 Neighboring gene zinc finger MYND-type containing 11 Neighboring gene prion like protein doppel Neighboring gene Ras association domain family member 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion/insertion polymorphisms of the prion protein gene (PRNP) in gayal (Bos frontalis). Memon S, et al. J Genet, 2018 Dec. PMID 30555062
  2. Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species. Vrentas CE, et al. BMC Res Notes, 2017 Dec 20. PMID 29262866, Free PMC Article
  3. Molecular dynamics simulations capture the misfolding of the bovine prion protein at acidic pH. Cheng CJ, et al. Biomolecules, 2014 Feb 10. PMID 24970211, Free PMC Article
  4. Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition. Hayashi T, et al. Nucleic Acids Res, 2014 Jun. PMID 24803670, Free PMC Article
  5. Spread of classic BSE prions from the gut via the peripheral nervous system to the brain. Kaatz M, et al. Am J Pathol, 2012 Aug. PMID 22781833

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.
    Title: Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.
  2. Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
    Title: Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
  3. Deletion/insertion polymorphisms of the PRNP gene is associated with bovine spongiformencephalopathy.
    Title: Deletion/insertion polymorphisms of the prion protein gene (PRNP) in gayal (Bos frontalis).
  4. Data suggest that the E211K prion protein provides the opportunity for future analysis of physiological changes over time.
    Title: Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species.
  5. Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle
    Title: Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.
  6. the data indicate a four-rung beta-solenoid structure as a key feature for the architecture of infectious mammalian prions.
    Title: The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.
  7. Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion
    Title: Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion.
  8. Misfolded structures, with nonnative beta-strands formed in the flexible N-terminal domain of PRNP were found in acidic pH simulations.
    Title: Molecular dynamics simulations capture the misfolding of the bovine prion protein at acidic pH.
  9. This work demonstrates that this isolate is transmissible, has a BSE-H phenotype when transmitted to cattle with the K211 polymorphism, and has molecular features that distinguish it from other cases of BSE-H described in the literature.
    Title: Clinical and pathologic features of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism.
  10. Genetic characterization of PRNP promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP and bovine prion-like Shadoo (SPRN) genes, are reported.
    Title: PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC140197

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
major prion protein; alternative prion protein
Names
major scrapie-associated fibril protein 1
prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
prion protein PrP
prion protein precursor PrP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271625.3 → NP_001258554.1  alternative prion protein isoform AltPrp

    See identical proteins and their annotated locations for NP_001258554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes a shorter protein from an overlapping reading frame, compared to variant 1. Alternative prion protein (AltPrp) has no similarity to the other protein encoded by this gene and localizes to the outer mitochondrial membrane.
    Source sequence(s)
    NKLS02000013
    UniProtKB/Swiss-Prot
    F7VJQ2
    UniProtKB/TrEMBL
    K0PBH2

  2. NM_001271626.3 → NP_001258555.1  major prion protein Isoform 1 precursor

    See identical proteins and their annotated locations for NP_001258555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    NKLS02000013
    UniProtKB/Swiss-Prot
    A1YVV9, P10279, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
    UniProtKB/TrEMBL
    A6YK35, D5G2D5
    Related
    ENSBTAP00000091075.1, ENSBTAT00000101610.1
    Conserved Domains (2) summary
    smart00157
    Location:25 → 251
    PRP; Major prion protein
    pfam11587
    Location:1 → 30
    Prion_bPrPp; Major prion protein bPrPp - N terminal

  3. NM_181015.4 → NP_851358.2  major prion protein Isoform 1 precursor

    See identical proteins and their annotated locations for NP_851358.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    NKLS02000013
    UniProtKB/Swiss-Prot
    A1YVV9, P10279, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
    UniProtKB/TrEMBL
    A6YK35, D5G2D5
    Related
    ENSBTAP00000086207.1, ENSBTAT00000090572.1
    Conserved Domains (2) summary
    smart00157
    Location:25 → 251
    PRP; Major prion protein
    pfam11587
    Location:1 → 30
    Prion_bPrPp; Major prion protein bPrPp - N terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47039937..47060168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F7VJQ2.1 GenPept UniProtKB/Swiss-Prot:F7VJQ2
P10279.2 GenPept UniProtKB/Swiss-Prot:P10279

Gene LinkOut

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Research Materials