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Reep3 receptor accessory protein 3 [ Mus musculus (house mouse) ]

Gene ID: 28193, updated on 9-Dec-2024

Summary

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Official Symbol
Reep3provided by MGI
Official Full Name
receptor accessory protein 3provided by MGI
Primary source
MGI:MGI:88930
See related
Ensembl:ENSMUSG00000019873 AllianceGenome:MGI:88930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D10Ucla1
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization and mitotic nuclear membrane reassembly. Predicted to be located in microtubule. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in several structures, including heart valve; limb segment; trigeminal ganglion; and ventricular layer. Orthologous to human REEP3 (receptor accessory protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 16.4), subcutaneous fat pad adult (RPKM 9.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Reep3 in Genome Data Viewer
Location:
10 B5.1; 10 34.83 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (66844968..66932767, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67009189..67096988, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110002J07 gene Neighboring gene STARR-seq mESC enhancer starr_26972 Neighboring gene STARR-seq mESC enhancer starr_26973 Neighboring gene STARR-positive B cell enhancer ABC_E5143 Neighboring gene STARR-positive B cell enhancer ABC_E6865 Neighboring gene STARR-seq mESC enhancer starr_26976 Neighboring gene predicted gene, 53603 Neighboring gene STARR-seq mESC enhancer starr_26978 Neighboring gene VISTA enhancer mm1692 Neighboring gene STARR-seq mESC enhancer starr_26980 Neighboring gene STARR-seq mESC enhancer starr_26981 Neighboring gene predicted gene, 31763 Neighboring gene STARR-positive B cell enhancer mm9_chr10:66531454-66531755 Neighboring gene STARR-positive B cell enhancer ABC_E8340 Neighboring gene STARR-seq mESC enhancer starr_26991 Neighboring gene STARR-seq mESC enhancer starr_26992 Neighboring gene jumonji domain containing 1C Neighboring gene STARR-positive B cell enhancer ABC_E10618 Neighboring gene predicted gene, 26359 Neighboring gene STARR-seq mESC enhancer starr_26997 Neighboring gene nuclear receptor binding factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The expression of the evolutionarily conserved GATA/GACA repeats in mouse tissues. Schäfer R, et al. Chromosoma, 1986. PMID 3755389
  2. In silico identification of new candidate genes for hereditary congenital facial paresis. Tomás-Roca L, et al. Int J Dev Neurosci, 2011 Jun. PMID 21345367
  3. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
  4. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
  5. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, et al. Genomics, 1993 Nov. PMID 8288233

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear membrane reassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204915.2 → NP_001191844.1  receptor expression-enhancing protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153382, AC156272
    Consensus CDS
    CCDS88015.1
    UniProtKB/TrEMBL
    A0A1W2P8A8
    Related
    ENSMUSP00000151994.2, ENSMUST00000217841.2
    Conserved Domains (1) summary
    pfam03134
    Location:7 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  2. NM_001428928.1 → NP_001415857.1  receptor expression-enhancing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153382, AC156272

  3. NM_001428929.1 → NP_001415858.1  receptor expression-enhancing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153382, AC156272

  4. NM_178606.6 → NP_848721.1  receptor expression-enhancing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_848721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC153382, AC156272
    Consensus CDS
    CCDS35926.1
    UniProtKB/Swiss-Prot
    Q99KK1, Q9CZM8, Q9D8G3
    Related
    ENSMUSP00000020023.8, ENSMUST00000020023.9
    Conserved Domains (1) summary
    pfam03134
    Location:7 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RNA

  1. NR_190541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153382, AC156272

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    66844968..66932767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513726.4 → XP_006513789.1  receptor expression-enhancing protein 3 isoform X1

    Conserved Domains (1) summary
    pfam03134
    Location:4 → 80
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  2. XM_006513727.2 → XP_006513790.1  receptor expression-enhancing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam03134
    Location:19 → 95
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  3. XM_006513728.2 → XP_006513791.1  receptor expression-enhancing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006513791.1

    Conserved Domains (1) summary
    pfam03134
    Location:19 → 95
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  4. XM_036155799.1 → XP_036011692.1  receptor expression-enhancing protein 3 isoform X3

    Conserved Domains (1) summary
    pfam03134
    Location:19 → 95
    TB2_DP1_HVA22; TB2/DP1, HVA22 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KK1.1 GenPept UniProtKB/Swiss-Prot:Q99KK1

Gene LinkOut

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