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Dhrs4 dehydrogenase/reductase 4 [ Mus musculus (house mouse) ]

Gene ID: 28200, updated on 9-Dec-2024

Summary

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Official Symbol
Dhrs4provided by MGI
Official Full Name
dehydrogenase/reductase 4provided by MGI
Primary source
MGI:MGI:90169
See related
Ensembl:ENSMUSG00000022210 AllianceGenome:MGI:90169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR; RRD; NDRD; PHCR; PSCD; mouNRDR; D14Ucla2
Summary
Enables retinal dehydrogenase activity. Acts upstream of or within retinal metabolic process. Located in mitochondrion and peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 28.9), liver E18 (RPKM 24.8) and 28 other tissues See more
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Genomic context

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See Dhrs4 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55715880..55727797)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55478741..55490340)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52145 Neighboring gene STARR-positive B cell enhancer ABC_E5438 Neighboring gene STARR-seq mESC enhancer starr_36769 Neighboring gene predicted gene, 41158 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. Lei Z, et al. Biochemistry, 2003 Apr 15. PMID 12680773
  2. Bioinformatic identification and characterization of new members of short-chain dehydrogenase/reductase superfamily. Keller B, et al. Mol Cell Endocrinol, 2006 Mar 27. PMID 16406282
  3. CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription. Su Z, et al. Genet Mol Res, 2016 Jun 3. PMID 27323117
  4. Proteomic analysis of SET-binding proteins. Vera J, et al. Proteomics, 2007 Feb. PMID 17309103
  5. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. Gabrielli F, et al. Gene, 2012 Dec 15. PMID 23036705

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An analysis of the relationship between the promoter characteristics and RNA expression of the DHRS4 gene cluster indicated that the development of CpG islands, in addition to the promoter sequence, during mammalian evolution could modulate the dose compensatory regulation of the copy number-varied DHRS4 gene cluster
    Title: CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.
  2. M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. M. musculus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
    Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-keto sterol reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonyl reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ketone metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 4
Names
NADPH-dependent carbonyl reductase
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
NADPH-dependent retinol dehydrogenase/reductase
dehydrogenase/reductase (SDR family) member 4
peroxisomal short-chain alcohol dehydrogenase
short chain dehydrogenase/reductase family 25C member 2
NP_001033027.2
NP_109611.1
XP_030103712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037938.2 → NP_001033027.2  dehydrogenase/reductase SDR family member 4 isoform 1

    See identical proteins and their annotated locations for NP_001033027.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159002, AK146988, BQ032668, BY291911
    Consensus CDS
    CCDS27111.1
    UniProtKB/Swiss-Prot
    G3X8V7, Q99LB2, Q9EQU4
    UniProtKB/TrEMBL
    Q3UIB5
    Related
    ENSMUSP00000022821.7, ENSMUST00000022821.8
    Conserved Domains (2) summary
    cd08936
    Location:24 → 279
    CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR
    PRK07231
    Location:31 → 274
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional

  2. NM_030686.2 → NP_109611.1  dehydrogenase/reductase SDR family member 4 isoform 2

    See identical proteins and their annotated locations for NP_109611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC159002, AK018788, AW125533, BY291911
    Consensus CDS
    CCDS88668.1
    UniProtKB/TrEMBL
    Q9D2U3
    Related
    ENSMUSP00000154481.2, ENSMUST00000226168.2
    Conserved Domains (1) summary
    cl21454
    Location:24 → 178
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55715880..55727797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247852.2 → XP_030103712.1  dehydrogenase/reductase SDR family member 4 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:24 → 137
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LB2.3 GenPept UniProtKB/Swiss-Prot:Q99LB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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