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TMEM150B transmembrane protein 150B [ Homo sapiens (human) ]

Gene ID: 284417, updated on 2-Nov-2024

Summary

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Official Symbol
TMEM150Bprovided by HGNC
Official Full Name
transmembrane protein 150Bprovided by HGNC
Primary source
HGNC:HGNC:34415
See related
Ensembl:ENSG00000180061 MIM:617291; AllianceGenome:HGNC:34415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTN2; DRAM3; TMEM224
Summary
This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in duodenum (RPKM 9.7), small intestine (RPKM 9.3) and 7 other tissues See more
Orthologs
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Genomic context

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See TMEM150B in Genome Data Viewer
Location:
19q13.42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55309444..55325341, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58404966..58429532, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55824169..55836709, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15080 Neighboring gene microRNA 6803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15084 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55768465-55768658 Neighboring gene Sharpr-MPRA regulatory region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55781781-55782280 Neighboring gene HSPA (Hsp70) binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55789069-55789569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11021 Neighboring gene BR serine/threonine kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55824387-55824912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55849388-55850162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55850163-55850936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55855204-55856008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55856009-55856814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55858005-55858699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11025 Neighboring gene lysine methyltransferase 5C Neighboring gene cytochrome c oxidase subunit 6B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Variation analysis of theTMEM150B gene in Chinese women with premature ovarian insufficiency. Shao T, et al. Reprod Biomed Online, 2019 Mar. PMID 30704953
  2. Another DRAM involved in autophagy and cell death. Mrschtik M, et al. Autophagy, 2016. PMID 27046253, Free PMC Article
  3. DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Mrschtik M, et al. Cell Death Differ, 2015 Oct. PMID 25929859, Free PMC Article
  4. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. Hong GS, et al. Neuron, 2016 Jul 6. PMID 27321926
  5. Plasticity of PI4KIIIα interactions at the plasma membrane. Chung J, et al. EMBO Rep, 2015 Mar. PMID 25608530, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of early menopause and the combined impact of identified variants.
EBI GWAS Catalog
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
EBI GWAS Catalog
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
modulator of macroautophagy TMEM150B
Names
DRAM-Related/Associated Member 3
hCG1651476
protein DRAM-3
tentonin 2
transmembrane protein 224
transmembrane protein LOC284417

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085488.3 → NP_001078957.1  modulator of macroautophagy TMEM150B isoform a

    See identical proteins and their annotated locations for NP_001078957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC020922, AU311823, BC171893
    Consensus CDS
    CCDS42629.1
    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 206
    Frag1; Frag1/DRAM/Sfk1 family

  2. NM_001282011.2 → NP_001268940.1  modulator of macroautophagy TMEM150B isoform a

    See identical proteins and their annotated locations for NP_001268940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC020922, AU311823, BC171904
    Consensus CDS
    CCDS42629.1
    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71
    Related
    ENSP00000320757.4, ENST00000326652.9
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 206
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. NR_104066.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020922, AU311823, BC171901, BC171904
    Related
    ENST00000586609.5

  2. NR_104071.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020922, AU311823, BC171893
    Related
    ENST00000592603.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55309444..55325341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526850.4 → XP_011525152.1  modulator of macroautophagy TMEM150B isoform X2

    Conserved Domains (1) summary
    pfam10277
    Location:4 → 168
    Frag1; Frag1/DRAM/Sfk1 family

  2. XM_047438674.1 → XP_047294630.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

  3. XM_047438669.1 → XP_047294625.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

  4. XM_017026667.3 → XP_016882156.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 206
    Frag1; Frag1/DRAM/Sfk1 family

  5. XM_047438673.1 → XP_047294629.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

  6. XM_005258812.5 → XP_005258869.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_005258869.1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 206
    Frag1; Frag1/DRAM/Sfk1 family

  7. XM_047438675.1 → XP_047294631.1  modulator of macroautophagy TMEM150B isoform X3

  8. XM_047438672.1 → XP_047294628.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

  9. XM_047438668.1 → XP_047294624.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

  10. XM_011526857.3 → XP_011525159.1  modulator of macroautophagy TMEM150B isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:1 → 146
    Frag1; Frag1/DRAM/Sfk1 family

  11. XM_047438671.1 → XP_047294627.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

  12. XM_011526856.4 → XP_011525158.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525158.1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 206
    Frag1; Frag1/DRAM/Sfk1 family

  13. XM_011526854.4 → XP_011525156.1  modulator of macroautophagy TMEM150B isoform X1

    See identical proteins and their annotated locations for XP_011525156.1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 206
    Frag1; Frag1/DRAM/Sfk1 family

  14. XM_047438670.1 → XP_047294626.1  modulator of macroautophagy TMEM150B isoform X1

    UniProtKB/Swiss-Prot
    A6NC51, B7ZW71

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58404966..58429532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320683.1 → XP_054176658.1  modulator of macroautophagy TMEM150B isoform X2

  2. XM_054320691.1 → XP_054176666.1  modulator of macroautophagy TMEM150B isoform X2

  3. XM_054320686.1 → XP_054176661.1  modulator of macroautophagy TMEM150B isoform X1

  4. XM_054320687.1 → XP_054176662.1  modulator of macroautophagy TMEM150B isoform X1

  5. XM_054320685.1 → XP_054176660.1  modulator of macroautophagy TMEM150B isoform X1

  6. XM_054320688.1 → XP_054176663.1  modulator of macroautophagy TMEM150B isoform X1

  7. XM_054320690.1 → XP_054176665.1  modulator of macroautophagy TMEM150B isoform X1

  8. XM_054320689.1 → XP_054176664.1  modulator of macroautophagy TMEM150B isoform X1

  9. XM_054320692.1 → XP_054176667.1  modulator of macroautophagy TMEM150B isoform X3

  10. XM_054320684.1 → XP_054176659.1  modulator of macroautophagy TMEM150B isoform X4

  11. XM_054320693.1 → XP_054176668.1  modulator of macroautophagy TMEM150B isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NC51.1 GenPept UniProtKB/Swiss-Prot:A6NC51

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