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GPR22 G protein-coupled receptor 22 [ Homo sapiens (human) ]

Gene ID: 2845, updated on 2-Nov-2024

Summary

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Official Symbol
GPR22provided by HGNC
Official Full Name
G protein-coupled receptor 22provided by HGNC
Primary source
HGNC:HGNC:4477
See related
Ensembl:ENSG00000172209 MIM:601910; AllianceGenome:HGNC:4477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 6.9), brain (RPKM 4.8) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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See GPR22 in Genome Data Viewer
Location:
7q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (107470057..107477845)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (108786096..108792223)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107110502..107116129)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901721 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene MPRA-validated peak6677 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:107031303-107031825 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene MPRA-validated peak6680 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:107148389-107148890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:107148891-107149390 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:107204244-107204454 Neighboring gene DUS4L-BCAP29 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18539 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:107204943-107206142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26493 Neighboring gene uncharacterized LOC124901856 Neighboring gene dihydrouridine synthase 4 like Neighboring gene B cell receptor associated protein 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effects of RNA degradation on gene expression analysis of human postmortem tissues. Lee J, et al. FASEB J, 2005 Aug. PMID 15955843
  2. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Kerkhof HJ, et al. Arthritis Rheum, 2010 Feb. PMID 20112360, Free PMC Article
  3. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. Chang CC, et al. BMC Cardiovasc Disord, 2024 May 30. PMID 38816768, Free PMC Article
  4. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Adams JW, et al. Am J Physiol Heart Circ Physiol, 2008 Aug. PMID 18539757
  5. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. O'Dowd BF, et al. Gene, 1997 Mar 10. PMID 9073069

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.
    Title: Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.
  2. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.
  3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
  4. Demonstrate GRR22 expression in human heart.
    Title: Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 22
Names
probable G-protein coupled receptor 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005295.3 → NP_005286.2  G-protein coupled receptor 22

    See identical proteins and their annotated locations for NP_005286.2

    Status: REVIEWED

    Source sequence(s)
    AC002381, AK122621, BC107128, DA519131, U66581
    Consensus CDS
    CCDS5744.1
    UniProtKB/Swiss-Prot
    A4D0R8, O14554, Q99680
    UniProtKB/TrEMBL
    B3KV13, Q3KNS9
    Related
    ENSP00000302676.4, ENST00000304402.6
    Conserved Domains (1) summary
    cd00637
    Location:44 → 370
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    107470057..107477845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420214.1 → XP_047276170.1  G-protein coupled receptor 22 isoform X1

    UniProtKB/Swiss-Prot
    A4D0R8, O14554, Q99680

  2. XM_011516056.4 → XP_011514358.1  G-protein coupled receptor 22 isoform X1

    See identical proteins and their annotated locations for XP_011514358.1

    UniProtKB/Swiss-Prot
    A4D0R8, O14554, Q99680
    UniProtKB/TrEMBL
    B3KV13, Q3KNS9
    Conserved Domains (1) summary
    cd00637
    Location:44 → 370
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p14 PATCHES

    Range
    315704..321332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332133.1 → XP_054188108.1  G-protein coupled receptor 22 isoform X1

    UniProtKB/Swiss-Prot
    A4D0R8, O14554, Q99680

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    108786096..108792223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357927.1 → XP_054213902.1  G-protein coupled receptor 22 isoform X1

    UniProtKB/Swiss-Prot
    A4D0R8, O14554, Q99680

  2. XM_054357926.1 → XP_054213901.1  G-protein coupled receptor 22 isoform X1

    UniProtKB/Swiss-Prot
    A4D0R8, O14554, Q99680
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99680.2 GenPept UniProtKB/Swiss-Prot:Q99680

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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