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GPR25 G protein-coupled receptor 25 [ Homo sapiens (human) ]

Gene ID: 2848, updated on 17-Sep-2024

Summary

Official Symbol
GPR25provided by HGNC
Official Full Name
G protein-coupled receptor 25provided by HGNC
Primary source
HGNC:HGNC:4480
See related
Ensembl:ENSG00000170128 MIM:602174; AllianceGenome:HGNC:4480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]
Orthologs
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Genomic context

See GPR25 in Genome Data Viewer
Location:
1q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200872981..200874178)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200129959..200131156)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200842109..200843306)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1677 Neighboring gene MPRA-validated peak646 silencer Neighboring gene calmodulin regulated spectrin associated protein family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200735945-200736445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200842161-200842803 Neighboring gene ribosomal protein L34 pseudogene 6 Neighboring gene MPRA-validated peak649 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1679 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200859988-200860816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200863922-200864432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200864433-200864944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200864945-200865455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200866179-200866766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200866767-200867356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1682 Neighboring gene innate immunity activator Neighboring gene RNA, U6 small nuclear 704, pseudogene Neighboring gene maestro heat like repeat family member 3, pseudogene

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human G protein-coupled receptor 25 (GPR25) at amino acid residues 315-316 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005298.4NP_005289.2  probable G-protein coupled receptor 25

    See identical proteins and their annotated locations for NP_005289.2

    Status: REVIEWED

    Source sequence(s)
    BC126386
    Consensus CDS
    CCDS1405.1
    UniProtKB/Swiss-Prot
    A0AVJ5, O00155
    Related
    ENSP00000301917.2, ENST00000304244.5
    Conserved Domains (1) summary
    pfam00001
    Location:56307
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    200872981..200874178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    200129959..200131156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)