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FAM153A family with sequence similarity 153 member A [ Homo sapiens (human) ]

Gene ID: 285596, updated on 10-Oct-2024

Summary

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Official Symbol
FAM153Aprovided by HGNC
Official Full Name
family with sequence similarity 153 member Aprovided by HGNC
Primary source
HGNC:HGNC:29940
See related
Ensembl:ENSG00000170074 AllianceGenome:HGNC:29940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NY-REN-7
Expression
Biased expression in testis (RPKM 10.8), spleen (RPKM 4.8) and 7 other tissues See more
Orthologs
all
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Genomic context

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See FAM153A in Genome Data Viewer
Location:
5q35.3
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177694247..177783425, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178237719..178327515, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177138050..177210426, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177033623-177034226 Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene SIMC1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16706 Neighboring gene uncharacterized LOC107986489 Neighboring gene MPRA-validated peak5597 silencer Neighboring gene uncharacterized LOC100419951 Neighboring gene FAM83G pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Scanlan MJ, et al. Int J Cancer, 1999 Nov 12. PMID 10508479
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Oct 30. PMID 9872452
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ75901, KIAA0752

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein FAM153A
Names
NY REN 7 antigen
renal carcinoma antigen NY-REN-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394339.1 → NP_001381268.1  protein FAM153A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140125
    Consensus CDS
    CCDS93833.1
    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Related
    ENSP00000481950.1, ENST00000614127.5

  2. NM_001413826.1 → NP_001400755.1  protein FAM153A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140125
    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3
    Related
    ENSP00000513119.1, ENST00000697116.2

  3. NM_173663.5 → NP_775934.3  protein FAM153A isoform 1

    See identical proteins and their annotated locations for NP_775934.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AC140125, AF155097, DA217331
    Consensus CDS
    CCDS34305.1
    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3
    UniProtKB/TrEMBL
    A0A8V8TKQ6
    Related
    ENSP00000513120.1, ENST00000697117.1
    Conserved Domains (1) summary
    pfam15722
    Location:178 → 310
    FAM153; FAM153 family

RNA

  1. NR_146226.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138819, AC140125, DB306163
    Related
    ENST00000503845.6

  2. NR_146227.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138819, AC140125, DB306163

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    177694247..177783425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009359.2 → XP_016864848.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  2. XM_017009358.2 → XP_016864847.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  3. XM_017009364.2 → XP_016864853.1  protein FAM153A isoform X5

    UniProtKB/TrEMBL
    A0A8V8TKQ6

  4. XM_017009369.2 → XP_016864858.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3
    UniProtKB/TrEMBL
    A0A8V8TKQ6
    Related
    ENSP00000513116.1, ENST00000697112.1
    Conserved Domains (1) summary
    pfam15722
    Location:178 → 310
    FAM153; FAM153 family

  5. XM_017009365.2 → XP_016864854.1  protein FAM153A isoform X6

    UniProtKB/TrEMBL
    A0A8V8TKQ6

  6. XM_017009363.2 → XP_016864852.1  protein FAM153A isoform X5

    UniProtKB/TrEMBL
    A0A8V8TKQ6

  7. XM_011534521.4 → XP_011532823.1  protein FAM153A isoform X7

    See identical proteins and their annotated locations for XP_011532823.1

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3
    UniProtKB/TrEMBL
    A0A8V8TKQ6
    Conserved Domains (1) summary
    pfam15722
    Location:178 → 310
    FAM153; FAM153 family

  8. XM_006714849.4 → XP_006714912.1  protein FAM153A isoform X7

    See identical proteins and their annotated locations for XP_006714912.1

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3
    UniProtKB/TrEMBL
    A0A8V8TKQ6
    Related
    ENSP00000513114.1, ENST00000697109.1
    Conserved Domains (1) summary
    pfam15722
    Location:178 → 310
    FAM153; FAM153 family

  9. XM_017009362.2 → XP_016864851.1  protein FAM153A isoform X4

    UniProtKB/TrEMBL
    A0A8V8TKQ6, A0A8V8TM68
    Related
    ENSP00000513109.1, ENST00000697103.1
    Conserved Domains (1) summary
    pfam15722
    Location:207 → 339
    FAM153; FAM153 family

  10. XM_047417108.1 → XP_047273064.1  protein FAM153A isoform X9

  11. XM_011534528.3 → XP_011532830.1  protein FAM153A isoform X8

    Conserved Domains (1) summary
    pfam15722
    Location:123 → 255
    FAM153; FAM153 family

  12. XM_011534520.3 → XP_011532822.1  protein FAM153A isoform X2

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A8V8TKN8
    Related
    ENSP00000513110.1, ENST00000697104.1
    Conserved Domains (1) summary
    pfam15722
    Location:253 → 385
    FAM153; FAM153 family

  13. XM_047417106.1 → XP_047273062.1  protein FAM153A isoform X3

  14. XM_017009356.2 → XP_016864845.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  15. XM_017009354.2 → XP_016864843.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  16. XM_005265889.4 → XP_005265946.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  17. XM_017009360.2 → XP_016864849.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  18. XM_017009361.2 → XP_016864850.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  19. XM_017009357.2 → XP_016864846.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  20. XM_017009352.2 → XP_016864841.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  21. XM_017009355.2 → XP_016864844.1  protein FAM153A isoform X1

    UniProtKB/Swiss-Prot
    A8MTI1, P0C7A2
    UniProtKB/TrEMBL
    A0A087WYN1
    Conserved Domains (1) summary
    pfam15722
    Location:255 → 387
    FAM153; FAM153 family

  22. XM_047417107.1 → XP_047273063.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    178237719..178327515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352402.1 → XP_054208377.1  protein FAM153A isoform X10

  2. XM_054352401.1 → XP_054208376.1  protein FAM153A isoform X10

  3. XM_054352410.1 → XP_054208385.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3

  4. XM_054352408.1 → XP_054208383.1  protein FAM153A isoform X5

  5. XM_054352412.1 → XP_054208387.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3

  6. XM_054352413.1 → XP_054208388.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3

  7. XM_054352409.1 → XP_054208384.1  protein FAM153A isoform X6

  8. XM_054352407.1 → XP_054208382.1  protein FAM153A isoform X5

  9. XM_054352414.1 → XP_054208389.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3

  10. XM_054352406.1 → XP_054208381.1  protein FAM153A isoform X13

  11. XM_054352411.1 → XP_054208386.1  protein FAM153A isoform X7

    UniProtKB/Swiss-Prot
    A8K0F3, O94852, Q9UHL3

  12. XM_054352416.1 → XP_054208391.1  protein FAM153A isoform X15

  13. XM_054352415.1 → XP_054208390.1  protein FAM153A isoform X14

  14. XM_054352404.1 → XP_054208379.1  protein FAM153A isoform X11

  15. XM_054352405.1 → XP_054208380.1  protein FAM153A isoform X12

  16. XM_054352400.1 → XP_054208375.1  protein FAM153A isoform X10

  17. XM_054352399.1 → XP_054208374.1  protein FAM153A isoform X10

  18. XM_054352396.1 → XP_054208371.1  protein FAM153A isoform X10

  19. XM_054352403.1 → XP_054208378.1  protein FAM153A isoform X10

  20. XM_054352398.1 → XP_054208373.1  protein FAM153A isoform X10

  21. XM_054352397.1 → XP_054208372.1  protein FAM153A isoform X10

  22. XM_054352395.1 → XP_054208370.1  protein FAM153A isoform X10

  23. XM_054352394.1 → XP_054208369.1  protein FAM153A isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHL3.2 GenPept UniProtKB/Swiss-Prot:Q9UHL3

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