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Trap1 TNF receptor-associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287069, updated on 10-Jul-2024

Summary

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Official Symbol
Trap1provided by RGD
Official Full Name
TNF receptor-associated protein 1provided by RGD
Primary source
RGD:1359733
See related
EnsemblRapid:ENSRNOG00000005418 AllianceGenome:RGD:1359733
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase binding activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Orthologous to human TRAP1 (TNF receptor associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 414.1), Adrenal (RPKM 373.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trap1 in Genome Data Viewer
Location:
10q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11971259..12005306)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11464882..11498931)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11724032..11757682)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095034 Neighboring gene uncharacterized LOC120095035 Neighboring gene CREB binding protein Neighboring gene deoxyribonuclease 1 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene NLR family, CARD domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tumor Necrosis Factor Receptor-Associated Protein 1 Protects against Mitochondrial Injury by Preventing High Glucose-Induced mPTP Opening in Diabetes. Liu L, et al. Oxid Med Cell Longev, 2020. PMID 32215175, Free PMC Article
  2. Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II. Xiang F, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27592455
  3. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. Masuda Y, et al. J Biol Chem, 2004 Oct 8. PMID 15292218
  4. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. Felts SJ, et al. J Biol Chem, 2000 Feb 4. PMID 10652318
  5. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Chen CF, et al. Mol Cell Biol, 1996 Sep. PMID 8756626, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor Necrosis Factor Receptor-Associated Protein 1 Protects against Mitochondrial Injury by Preventing High Glucose-Induced mPTP Opening in Diabetes.
    Title: Tumor Necrosis Factor Receptor-Associated Protein 1 Protects against Mitochondrial Injury by Preventing High Glucose-Induced mPTP Opening in Diabetes.
  2. tumor necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxia at least partly via potentiation of energy generation
    Title: Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC95278

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cellular respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in translational attenuation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational attenuation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heat shock protein 75 kDa, mitochondrial
Names
HSP 75
TNFR-associated protein 1
TRAP-1
tumor necrosis factor type 1 receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039001.1 → NP_001034090.1  heat shock protein 75 kDa, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001034090.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083909
    UniProtKB/Swiss-Prot
    Q5XHZ0
    UniProtKB/TrEMBL
    A0A8I6AFD9, A6K4T5
    Related
    ENSRNOP00000008966.4, ENSRNOT00000008966.6
    Conserved Domains (3) summary
    PRK05218
    Location:89 → 704
    PRK05218; heat shock protein 90; Provisional
    cd00075
    Location:114 → 223
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam00183
    Location:265 → 703
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    11971259..12005306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006952.1: Suppressed sequence

    Description
    NM_001006952.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XHZ0.1 GenPept UniProtKB/Swiss-Prot:Q5XHZ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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