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Gnptg N-acetylglucosamine-1-phosphate transferase subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 287134, updated on 2-Nov-2024

Summary

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Official Symbol
Gnptgprovided by RGD
Official Full Name
N-acetylglucosamine-1-phosphate transferase subunit gammaprovided by RGD
Primary source
RGD:1311614
See related
AllianceGenome:RGD:1311614
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gnptag
Summary
Contributes to UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. Predicted to be involved in carbohydrate phosphorylation. Located in Golgi membrane. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis III gamma. Orthologous to human GNPTG (N-acetylglucosamine-1-phosphate transferase subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 172.0), Brain (RPKM 147.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gnptg in Genome Data Viewer
Location:
10q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14756685..14761636, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14252186..14257128, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14593050..14597995, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095050 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene unk like zinc finger Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of UDP-N-acetylglucosamine-phosphotransferase-binding sites on the lysosomal proteases, cathepsins A, B, and D. Lukong KE, et al. Biochemistry, 1999 Jan 5. PMID 9890884
  2. Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes. Lang L, et al. J Biol Chem, 1984 Dec 10. PMID 6094568
  3. Lysosomal-enzyme targeting: the phosphorylation of synthetic D-mannosyl saccharides by UDP-N-acetyl-glucosamine:lysosomal-enzyme N-acetylglucosamine-phosphotransferase from rat-liver microsomes and fibroblasts. Madiyalakan R, et al. Carbohydr Res, 1986 Sep 1. PMID 3021329
  4. Post-translational modifications of the gamma-subunit affect intracellular trafficking and complex assembly of GlcNAc-1-phosphotransferase. Encarnação M, et al. J Biol Chem, 2011 Feb 18. PMID 21173149, Free PMC Article
  5. Molecular basis of variant pseudo-hurler polydystrophy (mucolipidosis IIIC). Raas-Rothschild A, et al. J Clin Invest, 2000 Mar. PMID 10712439, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetylglucosamine-1-phosphotransferase subunit gamma
Names
N-acetylglucosamine-1-phosphate transferase, gamma subunit
N-acetylglucosamine-1-phosphotransferase, gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100493.1 → NP_001093963.1  N-acetylglucosamine-1-phosphotransferase subunit gamma precursor

    See identical proteins and their annotated locations for NP_001093963.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158818
    UniProtKB/TrEMBL
    A0A9K3Y7E8, B0BNH1, F1LML8, Q4G066
    Conserved Domains (1) summary
    pfam07915
    Location:69 → 129
    PRKCSH; Glucosidase II beta subunit-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14756685..14761636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245935.5 → XP_006245997.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1

    UniProtKB/TrEMBL
    Q4G066
    Conserved Domains (2) summary
    pfam06464
    Location:178 → 261
    DMAP_binding; DMAP1-binding Domain
    pfam07915
    Location:69 → 129
    PRKCSH; Glucosidase II beta subunit-like protein

  2. XM_063268567.1 → XP_063124637.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2

  3. XM_063268568.1 → XP_063124638.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2

  4. XM_039085361.2 → XP_038941289.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2

    Conserved Domains (1) summary
    cl06793
    Location:5 → 54
    PRKCSH; Glucosidase II beta subunit-like protein
Nucleotide Protein Strain
Heading Accession and Version

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