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Pigq phosphatidylinositol glycan anchor biosynthesis, class Q [ Rattus norvegicus (Norway rat) ]

Gene ID: 287159, updated on 17-Aug-2024

Summary

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Official Symbol
Pigqprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Qprovided by RGD
Primary source
RGD:1359535
See related
EnsemblRapid:ENSRNOG00000020140 AllianceGenome:RGD:1359535
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to contribute to phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 77. Orthologous to human PIGQ (phosphatidylinositol glycan anchor biosynthesis class Q). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 201.0), Kidney (RPKM 188.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15447080..15463088, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14942571..14958584, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15289530..15305593, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 26 Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Neighboring gene Rab40c, member RAS oncogene family Neighboring gene uncharacterized LOC134480763 Neighboring gene proline rich 35 Neighboring gene ribosomal protein L36A, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. Hong Y, et al. J Biol Chem, 1999 Jun 25. PMID 10373468
  2. Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Tiede A, et al. Biochem J, 1998 Sep 15. PMID 9729469, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93737

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
Names
phosphatidylinositol glycan, class Q
NP_001007608.1
XP_006246004.1
XP_017452559.1
XP_038941294.1
XP_063124640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007607.1 → NP_001007608.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

    See identical proteins and their annotated locations for NP_001007608.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081875
    UniProtKB/TrEMBL
    A0A8I5ZV93, F7F5K8, Q642B8
    Related
    ENSRNOP00000027353.3, ENSRNOT00000027353.6
    Conserved Domains (1) summary
    pfam05024
    Location:303 → 463
    Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15447080..15463088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597070.3 → XP_017452559.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV93
    Conserved Domains (1) summary
    pfam05024
    Location:318 → 463
    Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

  2. XM_039085366.2 → XP_038941294.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV93, F7F5K8, Q642B8
    Conserved Domains (1) summary
    pfam05024
    Location:303 → 463
    Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

  3. XM_063268570.1 → XP_063124640.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV93

  4. XM_006245942.5 → XP_006246004.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1

    See identical proteins and their annotated locations for XP_006246004.1

    UniProtKB/TrEMBL
    A0A8I5ZV93, F7F5K8, Q642B8
    Conserved Domains (1) summary
    pfam05024
    Location:303 → 463
    Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

RNA

  1. XR_005489717.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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