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Ephb3 Eph receptor B3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287989, updated on 10-Oct-2024

Summary

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Official Symbol
Ephb3provided by RGD
Official Full Name
Eph receptor B3provided by RGD
Primary source
RGD:1305602
See related
EnsemblRapid:ENSRNOG00000031801 AllianceGenome:RGD:1305602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable axon guidance receptor activity and transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; neuron projection development; and tube morphogenesis. Predicted to act upstream of or within central nervous system projection neuron axonogenesis and retinal ganglion cell axon guidance. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Biomarker of malaria. Orthologous to human EPHB3 (EPH receptor B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 35.2), Brain (RPKM 12.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ephb3 in Genome Data Viewer
Location:
11q23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93345098..93363775, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (79840668..79859345, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83527960..83546742, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1, pseudogene 3 Neighboring gene nudix hydrolase 2, pseudogene 1 Neighboring gene uncharacterized LOC134481030 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration. Lin B, et al. Nat Commun, 2015 Apr 8. PMID 25851023, Free PMC Article
  2. EphB3 receptor and ligand expression in the adult rat brain. Willson CA, et al. J Mol Histol, 2006 Nov. PMID 17103029
  3. Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression. Willson CA, et al. Cell Transplant, 2003. PMID 12797382
  4. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. Miao H, et al. J Biol Chem, 2005 Jan 14. PMID 15536074
  5. PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. Böhme B, et al. Oncogene, 1993 Oct. PMID 8397371

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin.
    Title: Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin.
  2. Study found up-regulated expression of ephrinB3/EphB3 in intractable temporal lobe epilepsy patients and experimental temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3 might be involved in the pathogenesis of temporal lobe epilepsy
    Title: Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model.
  3. Breast cancer cell motility is regulated in part by Ephb3 signaling.
    Title: Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration.
  4. EphB3 may play a role in the maintenance of mature neuronal connections or re-arrangement of synaptic connections during late stages of development.
    Title: EphB3 receptor and ligand expression in the adult rat brain.
  5. EphB3 is upregulated after spinal cord injury; this may contribute to an environment in the spinal cord that is inhibitory to axonal regeneration.
    Title: Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables axon guidance receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within central nervous system projection neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in corpus callosum development ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in thymus development ISO
Inferred from Sequence Orthology
more info
  
involved_in urogenital system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ephrin type-B receptor 3
Names
EPH-like tyrosine kinase-2
NP_001401917.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414988.1 → NP_001401917.1  ephrin type-B receptor 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I5ZVE3
    Related
    ENSRNOP00000083114.1, ENSRNOT00000119527.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    93345098..93363775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105868.1: Suppressed sequence

    Description
    NM_001105868.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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