GRIA1 glutamate ionotropic receptor AMPA type subunit 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRIA1provided by HGNC
Official Full Name: glutamate ionotropic receptor AMPA type subunit 1provided by HGNC
Primary source: HGNC:HGNC:4571
See related: Ensembl:ENSG00000155511 MIM:138248; AllianceGenome:HGNC:4571
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLUH1; GLUR1; GLURA; GluA1; HBGR1; MRD67; MRT76
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 23.3) and lung (RPKM 3.7) See more
Orthologs: mouse all
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Genomic context

Location:: 5q33.2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (153489615..153813869)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (154022776..154347051)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (152870230..153193429)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Timely insertion of AMPA receptor in developing vestibular circuits is required for manifestation of righting reflexes and effective navigation.
Title: Timely insertion of AMPA receptor in developing vestibular circuits is required for manifestation of righting reflexes and effective navigation.
Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.
Title: Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.
MicroRNA miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture by inhibiting the glutamate AMPA receptor subunit 1 gene (GRIA1).
Title: MicroRNA miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture by inhibiting the glutamate AMPA receptor subunit 1 gene (GRIA1).
GluA1-homomeric AMPA receptor in synaptic plasticity and neurological diseases.
Title: GluA1-homomeric AMPA receptor in synaptic plasticity and neurological diseases.
AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone.
Title: AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone.
The Identification of Three Key Genes Related to Stemness in Thyroid Carcinoma through Comprehensive Analysis.
Title: The Identification of Three Key Genes Related to Stemness in Thyroid Carcinoma through Comprehensive Analysis.
Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease.
Title: Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease.
Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
Title: Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
these data demonstrate that M1 receptor activation induces membrane insertion of GluA1 via a signaling linking cAMP-PKA and PI3K-Akt-mTOR pathways but is irrelevant to protein synthesis.
Title: M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt.
Nanoscale mobility of resting AMPA receptors predetermines responsiveness to neurotransmitter, allosteric anions and TARP auxiliary subunits. Mobility at rest is regulated by alternative splicing of the flip/flop cassette of the ligand-binding domain, which controls motions in the distant AMPA receptor N-terminal domain (NTD).
Title: Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual developmental disorder, autosomal dominant 67 MedGen: C5677006 OMIM: 619927 GeneReviews: Not available	Compare labs
Intellectual developmental disorder, autosomal recessive 76 MedGen: C5677007 OMIM: 619931 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of aging. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of anthropometric traits in Korcula Island, Croatia. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of glutamate receptor 1 is significantly upregulated in clade B Tat treated SK-N-MC neuroblastoma cells	PubMed
	tat	HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-M64752 (e-PCR)
- UniSTS:25861

GRIA1 (e-PCR)
- UniSTS:181769

G15853 (e-PCR)
- UniSTS:66337

GRIA1 (e-PCR)
- UniSTS:504869

RH45466 (e-PCR)
- UniSTS:60735

SHGC-111262 (e-PCR)
- UniSTS:168259

D5S1978 (e-PCR), detects polymorphism
- UniSTS:82807

RH119775 (e-PCR)
- UniSTS:133251

A001Y15 (e-PCR)
- UniSTS:56981

G19777 (e-PCR)
- UniSTS:56982

WI-18998 (e-PCR)
- UniSTS:49308

GRIA1_1985 (e-PCR)
- UniSTS:280744

RH26210 (e-PCR)
- UniSTS:86451

RH15881 (e-PCR)
- UniSTS:57523

D5S2007 (e-PCR), detects polymorphism
- UniSTS:48072

SHGC-106132 (e-PCR)
- UniSTS:169686

SHGC-149610 (e-PCR)
- UniSTS:177113

SHGC-143689 (e-PCR)
- UniSTS:172014

STS-M64752 (e-PCR)
- UniSTS:24817

RH36674 (e-PCR)
- UniSTS:87799

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables AMPA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMPA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables AMPA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables adenylate cyclase binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-2 adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables glutamate-gated calcium ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables immunoglobulin binding	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables myosin V binding	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in behavioral response to pain	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amine stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ammonium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dsRNA	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in conditioned place preference	IEA Inferred from Electronic Annotation more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to fungicide	IEA Inferred from Electronic Annotation more info
involved_in response to lithium ion	IEA Inferred from Electronic Annotation more info
involved_in response to morphine	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in response to psychosocial stress	IEA Inferred from Electronic Annotation more info
involved_in response to sucrose	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in ER to Golgi transport vesicle membrane	TAS Traceable Author Statement more info
located_in axonal spine	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	TAS Traceable Author Statement more info
located_in excitatory synapse	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuron spine	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body membrane	IEA Inferred from Electronic Annotation more info
located_in perisynaptic space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density, intracellular component	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
located_in proximal dendrite	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor 1

Names: AMPA 1; AMPA receptor subunit GluA1; AMPA-selective glutamate receptor 1; gluR-1; gluR-A; gluR-K1; glutamate receptor, ionotropic, AMPA 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047078.1 RefSeqGene

Range

5975..329174

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000827.4 → NP_000818.2 glutamate receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_000818.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AB209094, AK310189, AL120214, DC335107, M81886, X58633

Consensus CDS

CCDS4322.1

UniProtKB/Swiss-Prot

B7Z2S0, B7Z2W8, B7Z3F6, B7Z9G9, D3DQI4, E7ESV8, P42261, Q2NKM6

UniProtKB/TrEMBL

A8K0K0

Related

ENSP00000285900.4, ENST00000285900.10

Conserved Domains (2) summary

cd13729
Location:406 → 787

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06390
Location:26 → 392

PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
NM_001114183.2 → NP_001107655.1 glutamate receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001107655.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a different coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is the same length but has a different internal segment, as compared to isoform 1.

Source sequence(s)

AB209094, AL120214, DC335107, M64752

Consensus CDS

CCDS47318.1

UniProtKB/TrEMBL

A8K0K0

Related

ENSP00000339343.5, ENST00000340592.10

Conserved Domains (2) summary

cd13729
Location:406 → 787

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06390
Location:26 → 392

PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
NM_001258019.2 → NP_001244948.1 glutamate receptor 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001244948.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB209094, AK295827, AL120214

Consensus CDS

CCDS58986.1

UniProtKB/TrEMBL

A8K0K0

Related

ENSP00000427920.1, ENST00000518142.5

Conserved Domains (2) summary

cd13729
Location:326 → 707

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:26 → 312

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
NM_001258020.2 → NP_001244949.1 glutamate receptor 1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (4) is shorter at the N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.

Source sequence(s)

AB209094, AL120214, DC335107

UniProtKB/TrEMBL

Q59GL5

Conserved Domains (4) summary

cd13729
Location:311 → 692

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:443 → 722

Lig_chan; Ligand-gated ion channel

pfam01094
Location:1 → 277

ANF_receptor; Receptor family ligand binding region

cl10011
Location:1 → 294

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
NM_001258021.2 → NP_001244950.1 glutamate receptor 1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (5) has a longer and distinct N-terminus compared to isoform 1.

Source sequence(s)

AB209094, AK295184, AK295827, AK315934, AL120214

Consensus CDS

CCDS58987.1

UniProtKB/TrEMBL

A8K0K0

Related

ENSP00000428994.1, ENST00000518783.1

Conserved Domains (4) summary

cd06390
Location:36 → 399

PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

cd13729
Location:416 → 797

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 827

Lig_chan; Ligand-gated ion channel

pfam01094
Location:47 → 382

ANF_receptor; Receptor family ligand binding region
NM_001258022.2 → NP_001244951.1 glutamate receptor 1 isoform 6

See identical proteins and their annotated locations for NP_001244951.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate exon in place of the 5'-most exon of variant 1 and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (6) has a longer and distinct N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.

Source sequence(s)

AB209094, AK295184, AK315934, AL120214

Consensus CDS

CCDS58988.1

UniProtKB/TrEMBL

A8K0K0

Related

ENSP00000415569.2, ENST00000448073.8

Conserved Domains (4) summary

cd06390
Location:36 → 399

PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

cd13729
Location:416 → 797

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 827

Lig_chan; Ligand-gated ion channel

pfam01094
Location:47 → 382

ANF_receptor; Receptor family ligand binding region
NM_001258023.1 → NP_001244952.1 glutamate receptor 1 isoform 7

See identical proteins and their annotated locations for NP_001244952.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AB209094, AK295039, AL120214

Consensus CDS

CCDS58989.1

UniProtKB/TrEMBL

Q59GL5

Related

ENSP00000427864.2, ENST00000521843.6

Conserved Domains (2) summary

cd13729
Location:337 → 718

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:1 → 323

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
NM_001364165.2 → NP_001351094.1 glutamate receptor 1 isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AC010613, AC091960, AC091962

UniProtKB/TrEMBL

A8K0K0

Conserved Domains (2) summary

cd13729
Location:350 → 731

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:26 → 336

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
NM_001364166.2 → NP_001351095.1 glutamate receptor 1 isoform 9

Status: REVIEWED

Source sequence(s)

AC010613, AC091960, AC091962

UniProtKB/TrEMBL

A0A9L9PXG3, A8K0K0

Related

ENSP00000516521.1, ENST00000706734.1

Conserved Domains (2) summary

cd06390
Location:35 → 398

PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

cd13729
Location:415 → 796

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
NM_001364167.2 → NP_001351096.1 glutamate receptor 1 isoform 10

Status: REVIEWED

Source sequence(s)

AC010613, AC091960, AC091962

UniProtKB/TrEMBL

Q59GL5

Conserved Domains (2) summary

cd13729
Location:337 → 718

PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:1 → 323

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RNA

NR_047578.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate 5' exon and an alternate 3' exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.

Source sequence(s)

AB209094, AC091960, AK294011, AL120214
NR_157093.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC010613, AC091960, AC091962

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

153489615..153813869

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417128.1 → XP_047273084.1 glutamate receptor 1 isoform X1
XM_017009392.2 → XP_016864881.1 glutamate receptor 1 isoform X2

UniProtKB/TrEMBL

B7Z1W1