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TAg large T antigen [ Betapolyomavirus secumuris ]

Gene ID: 29031024, updated on 5-May-2023

Summary

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Gene symbol
TAg
Gene description
large T antigen
Locus tag
MPtVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Betapolyomavirus secumuris (strain: Kilham)
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Betapolyomavirus
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Genomic context

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Sequence:
NC_001505.2 (340..2547)

NC_001505.2Genomic Context describing neighboring genes Neighboring gene Small T antigen Neighboring gene Major capsid protein VP1 Neighboring gene capsid protein VP3 Neighboring gene capsid protein VP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001505.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence and genome organization of the murine polyomavirus, Kilham strain. Mayer M, et al. Virology, 1991 Apr. PMID 1849675

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Miscellaneous features

  • Loc: 574-582 splice donor site
  • Loc: 834-844 splice acceptor site

General protein information

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Preferred Names
large T antigen
NP_041232.1
  • large T antigen; binds to the viral origin of replication; regulates the transcription of early region mRNA; helicase activity facilitates movement of the virion DNA replication fork; the small T antigen shares a region in common with the large T antigen known as the J-domain; the J-domain is required for multiple processes including assembly, viral genomic DNA replication and transcription; The polyomaviruses are non-enveloped dsDNA viruses; the viral genome is organized into two divergent transcriptional units known as early and late regions; mRNAs from the early region encode the viral small and large t-antigens; the small T antigen and large T antigen are expressed upon entry into the host nucleus early in the viral lifecycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001505.2 Reference assembly

    Range
    340..2547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_041232.1 T-antigen [Betapolyomavirus secumuris]

    See identical proteins and their annotated locations for NP_041232.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P24597
    Conserved Domains (4) summary
    smart00271
    Location:11 → 63
    DnaJ; DnaJ molecular chaperone homology domain
    PHA02624
    Location:1 → 646
    PHA02624; large T antigen; Provisional
    pfam02217
    Location:151 → 247
    T_Ag_DNA_bind; Origin of replication binding protein
    pfam06431
    Location:282 → 627
    Polyoma_lg_T_C; Polyomavirus large T antigen C-terminus
Nucleotide Protein
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