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Rbm17 RNA binding motif protein 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291295, updated on 2-Nov-2024

Summary

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Official Symbol
Rbm17provided by RGD
Official Full Name
RNA binding motif protein 17provided by RGD
Primary source
RGD:1311208
See related
EnsemblRapid:ENSRNOG00000018767 AllianceGenome:RGD:1311208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 272.1), Spleen (RPKM 177.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm17 in Genome Data Viewer
Location:
17q12.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71846941..71863834)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66937140..66954034)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (70586345..70603289)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 5-like, pseudogene 2 Neighboring gene interleukin 2 receptor subunit alpha Neighboring gene proteasome 26S subunit, ATPase 6, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Neighboring gene uncharacterized LOC120097756 Neighboring gene uncharacterized LOC134482599

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Corsini L, et al. Nat Struct Mol Biol, 2007 Jul. PMID 17589525
  2. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, et al. Nature, 2008 Apr 10. PMID 18337722, Free PMC Article
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
splicing factor 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013058.1 → NP_001013076.1  splicing factor 45

    See identical proteins and their annotated locations for NP_001013076.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079248
    UniProtKB/TrEMBL
    A0A8I5ZW65, Q6AY02
    Related
    ENSRNOP00000083907.1, ENSRNOT00000106718.2
    Conserved Domains (2) summary
    pfam01585
    Location:235 → 279
    G-patch; G-patch domain
    cd12647
    Location:307 → 401
    RRM_UHM_SPF45; RNA recognition motif (RRM) found in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    71846941..71863834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254205.4 → XP_006254267.1  splicing factor 45 isoform X1

    See identical proteins and their annotated locations for XP_006254267.1

    UniProtKB/TrEMBL
    A0A8I5ZW65, Q6AY02
    Related
    ENSRNOP00000025550.3, ENSRNOT00000025550.8
    Conserved Domains (2) summary
    pfam01585
    Location:235 → 279
    G-patch; G-patch domain
    cd12647
    Location:307 → 401
    RRM_UHM_SPF45; RNA recognition motif (RRM) found in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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