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Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291677, updated on 10-Oct-2024

Summary

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Official Symbol
Dnajc18provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C18provided by RGD
Primary source
RGD:1310237
See related
EnsemblRapid:ENSRNOG00000019995 AllianceGenome:RGD:1310237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310237
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 319.0), Brain (RPKM 172.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc18 in Genome Data Viewer
Location:
18p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27543438..27577535, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27269350..27303453, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28466892..28501013, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene proline-rich basic protein 1 Neighboring gene spermatogenesis associated 24 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene small integral membrane protein 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 18
Names
DnaJ (Hsp40) homolog, subfamily C, member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013887.2 → NP_001013909.1  dnaJ homolog subfamily C member 18 isoform 1

    See identical proteins and their annotated locations for NP_001013909.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I5ZNW9, Q6AXW3
    Related
    ENSRNOP00000079625.2, ENSRNOT00000097174.2
    Conserved Domains (2) summary
    pfam00226
    Location:41 → 102
    DnaJ; DnaJ domain
    pfam09320
    Location:209 → 308
    DUF1977; Domain of unknown function (DUF1977)

  2. NM_001398603.1 → NP_001385532.1  dnaJ homolog subfamily C member 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F7F826, Q0H8V1
    Related
    ENSRNOP00000027194.6, ENSRNOT00000027194.8
    Conserved Domains (2) summary
    PRK14298
    Location:81 → 182
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:249 → 349
    DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27543438..27577535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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