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Ciao1 cytosolic iron-sulfur assembly component 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29231, updated on 19-Jun-2024

Summary

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Official Symbol
Ciao1provided by RGD
Official Full Name
cytosolic iron-sulfur assembly component 1provided by RGD
Primary source
RGD:1307285
See related
Ensembl:ENSRNOG00000012638 AllianceGenome:RGD:1307285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr39
Summary
Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytoplasm. Predicted to be part of CIA complex and MMXD complex. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 162.7), Muscle (RPKM 159.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ciao1 in Genome Data Viewer
Location:
3q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134913639..134919244, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114458671..114465928, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119671778..119677324, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ITPRIP like 1 Neighboring gene small nuclear ribonucleoprotein U5 subunit 200 Neighboring gene transmembrane protein 127 Neighboring gene StAR-related lipid transfer domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Srinivasan V, et al. Structure, 2007 Oct. PMID 17937914
  2. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
  3. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Ito S, et al. Mol Cell, 2010 Aug 27. PMID 20797633
  4. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway. Seki M, et al. J Biol Chem, 2013 Jun 7. PMID 23585563, Free PMC Article
  5. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Gari K, et al. Science, 2012 Jul 13. PMID 22678361

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95143

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in iron-sulfur cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation by iron-sulfur cluster transfer ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of MMXD complex IEA
Inferred from Electronic Annotation
more info
  
part_of MMXD complex ISO
Inferred from Sequence Orthology
more info
  
part_of MMXD complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
probable cytosolic iron-sulfur protein assembly protein CIAO1
Names
WD repeat domain 39
WD repeat-containing protein 39
WD40 protein Ciao1
cytosolic iron-sulfur protein assembly 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008766.1 → NP_001008766.1  probable cytosolic iron-sulfur protein assembly protein CIAO1

    See identical proteins and their annotated locations for NP_001008766.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088474
    UniProtKB/Swiss-Prot
    Q5M7T1
    UniProtKB/TrEMBL
    A0A8L2UJ40, A6HQ07
    Related
    ENSRNOP00000017603.4, ENSRNOT00000017603.6
    Conserved Domains (3) summary
    COG2319
    Location:22 → 335
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:17 → 332
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:19 → 58
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    134913639..134919244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104428.2 → XP_038960356.1  probable cytosolic iron-sulfur protein assembly protein CIAO1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7Q2
    Related
    ENSRNOP00000089224.1
    Conserved Domains (2) summary
    cd00200
    Location:17 → 221
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:19 → 58
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_010064575.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M7T1.1 GenPept UniProtKB/Swiss-Prot:Q5M7T1

Gene LinkOut

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