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Rgs4 regulator of G-protein signaling 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29480, updated on 28-Oct-2024

Summary

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Official Symbol
Rgs4provided by RGD
Official Full Name
regulator of G-protein signaling 4provided by RGD
Primary source
RGD:3567
See related
EnsemblRapid:ENSRNOG00000002773 AllianceGenome:RGD:3567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 760.9), Adrenal (RPKM 271.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rgs4 in Genome Data Viewer
Location:
13q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (84469593..84475884, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (81936775..81943103, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (88054817..88061108, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 7 Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene regulator of G-protein signaling 5 Neighboring gene uncharacterized LOC134481531 Neighboring gene coiled-coil domain containing 190 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7. Lan KL, et al. J Biol Chem, 2000 Oct 27. PMID 10942773
  2. RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia. Gu Z, et al. Mol Pharmacol, 2007 Apr. PMID 17220354
  3. Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum. Schwendt M, et al. Neuroreport, 2007 Aug 6. PMID 17632279
  4. Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. Lin TC, et al. Epilepsy Behav, 2009 Feb. PMID 19126440
  5. RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Ding J, et al. Nat Neurosci, 2006 Jun. PMID 16699510

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
    Title: The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
  2. Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
    Title: Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
  3. LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
    Title: LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
  4. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling
    Title: Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
  5. After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
    Title: Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
  6. Data suggest that RGS4 proteins play an important pathophysiological role in the development and expression of l-DOPA-induced dyskinesia
    Title: RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.
  7. partial agonism of the M2 muscarinic receptor is regulated by the RGS4-mediated inhibition of G-protein signalling
    Title: RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
  8. Tra2beta regulates the expression of RGS4 gene and is induced by morphine.
    Title: Splicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphine.
  9. Rgs4 transcript is readily detected but does not respond to hypoxia. Furthermore, this regulation was found to be dependent on transcription, and occurs in a manner consistent with direct HIF transactivation of Rgs4 transcription
    Title: Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway.
  10. data demonstrate that RGS4 in the dorsal striatum attenuates amphetamine-induced ERK signaling and decreases the behavioral efficacy of acute amphetamine likely by limiting mGluR5 function
    Title: RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dorsal root ganglion development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of glycine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 4
Names
RGP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017214.2 → NP_058910.1  regulator of G-protein signaling 4

    See identical proteins and their annotated locations for NP_058910.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P49799
    UniProtKB/TrEMBL
    A0A8I5Y8W6, A6IDM9
    Related
    ENSRNOP00000003774.2, ENSRNOT00000003774.4
    Conserved Domains (1) summary
    cd08714
    Location:63 → 176
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    84469593..84475884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49799.1 GenPept UniProtKB/Swiss-Prot:P49799

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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