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Etfdh electron transfer flavoprotein dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 295143, updated on 17-Aug-2024

Summary

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Official Symbol
Etfdhprovided by RGD
Official Full Name
electron transfer flavoprotein dehydrogenaseprovided by RGD
Primary source
RGD:735052
See related
EnsemblRapid:ENSRNOG00000009538 AllianceGenome:RGD:735052
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables electron transfer activity and iron-sulfur cluster binding activity. Predicted to be involved in electron transport chain; fatty acid beta-oxidation using acyl-CoA dehydrogenase; and response to oxidative stress. Located in mitochondrial membrane. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1358.2), Liver (RPKM 820.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Etfdh in Genome Data Viewer
Location:
2q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (167038707..167060758, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (164740547..164762754, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (178367547..178389641, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene folliculin interacting protein 2 Neighboring gene peptidylprolyl isomerase D Neighboring gene similar to human chromosome 4 open reading frame 46 Neighboring gene relaxin family peptide receptor 1 Neighboring gene uncharacterized LOC108350043

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning, functional expression and cellular localization of rat liver mitochondrial electron-transfer flavoprotein-ubiquinone oxidoreductase protein. Huang S, et al. Sci China C Life Sci, 2005 Aug. PMID 16248429
  2. The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene. Gempel K, et al. Brain, 2007 Aug. PMID 17412732, Free PMC Article
  3. Alternative quinone substrates and inhibitors of human electron-transfer flavoprotein-ubiquinone oxidoreductase. Simkovic M, et al. Biochem J, 2004 Mar 1. PMID 14640977, Free PMC Article
  4. Expression of human electron transfer flavoprotein-ubiquinone oxidoreductase from a baculovirus vector: kinetic and spectral characterization of the human protein. Simkovic M, et al. Biochem J, 2002 Jun 15. PMID 12049629, Free PMC Article
  5. Electron-transfer flavoprotein-ubiquinone oxidoreductase from pig liver: purification and molecular, redox, and catalytic properties. Beckmann JD, et al. Biochemistry, 1985 Jul 16. PMID 4052375

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A 32 amino acid peptide was a mitochondrial targeting peptide, and both FAD and iron-sulfur cluster were inserted properly into the recombinant enzyme.
    Title: cDNA cloning, functional expression and cellular localization of rat liver mitochondrial electron-transfer flavoprotein-ubiquinone oxidoreductase protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93785

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquinone binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Names
ETF dehydrogenase
ETF-QO
ETF-ubiquinone oxidoreductase
electron transferring flavoprotein dehydrogenase
NP_942037.2
XP_006232569.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198742.2 → NP_942037.2  electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_942037.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081890
    UniProtKB/Swiss-Prot
    Q6UPE1
    UniProtKB/TrEMBL
    F2W8A8, Q66HF3
    Related
    ENSRNOP00000077926.2, ENSRNOT00000105634.2
    Conserved Domains (3) summary
    COG0644
    Location:66 → 528
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:511 → 614
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:67 → 261
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    167038707..167060758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232507.2 → XP_006232569.1  electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UPE1
    UniProtKB/TrEMBL
    F7ELJ5
    Related
    ENSRNOP00000013262.5, ENSRNOT00000013262.8
    Conserved Domains (3) summary
    COG0644
    Location:66 → 479
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:462 → 565
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:67 → 216
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UPE1.1 GenPept UniProtKB/Swiss-Prot:Q6UPE1

Gene LinkOut

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