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US8 envelope glycoprotein E [ Suid alphaherpesvirus 1 ]

Gene ID: 2952517, updated on 18-Aug-2023

Summary

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Gene symbol
US8
Gene description
envelope glycoprotein E
Locus tag
SuHV1_gp70
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_006151.1 (123452..125732)

NC_006151.1Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase US3 Neighboring gene envelope glycoprotein G Neighboring gene envelope glycoprotein D Neighboring gene envelope glycoprotein I Neighboring gene membrane protein US9 Neighboring gene virion protein US2 Neighboring gene regulatory protein ICP22 Neighboring gene transcriptional regulator ICP4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006151.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation. Lu M, et al. Virus Res, 2021 Jan 2. PMID 33152381
  2. Polymorphisms affecting the gE and gI proteins partly contribute to the virulence of a newly-emergent highly virulent Chinese pseudorabies virus. Dong J, et al. Virology, 2018 Jun. PMID 29631175
  3. Deletion of the us7 and us8 genes of pseudorabies virus exerts a differential effect on the expression of early and late viral genes. Póka N, et al. Virus Genes, 2017 Aug. PMID 28477233
  4. A live gI/gE-deleted pseudorabies virus (PRV) protects weaned piglets against lethal variant PRV challenge. Yin Y, et al. Virus Genes, 2017 Aug. PMID 28417300
  5. Formation of Pseudorabies virus glycoprotein E/I complex in baculovirus recombinant system. Tyborowska J, et al. Acta Virol, 2006. PMID 17131935

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pseudorabies virus glycoprotein gE suppresses interferon-beta production via CREB-binding protein degradation.
    Title: Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
  2. findings demonstrated that polymorphisms in US8 (gE)and US7 (gI) of ZJ01 partly contribute to the virulence of PRV strain ZJ01 in pigs
    Title: Polymorphisms affecting the gE and gI proteins partly contribute to the virulence of a newly-emergent highly virulent Chinese pseudorabies virus.
  3. gI/gE-deleted pseudorabies virus (PRV) protects weaned piglets against lethal variant pseudorabies virus challenge.
    Title: A live gI/gE-deleted pseudorabies virus (PRV) protects weaned piglets against lethal variant PRV challenge.
  4. Abrogation of the us7/8 gene function was found to exert a drastic but differential effect on the expression of PRV genes during lytic infection.
    Title: Deletion of the us7 and us8 genes of pseudorabies virus exerts a differential effect on the expression of early and late viral genes.
  5. Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
    Title: Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells.
  6. This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
    Title: Pseudorabies virus triggers glycoprotein gE-mediated ERK1/2 activation and ERK1/2-dependent migratory behavior in T cells.
  7. N-terminal domains of gE and gI containing first 122 and 106 aa, respectively, were sufficient for the glycoprotein E/I complex complex formation in baculovirus recombinant system.
    Title: Formation of Pseudorabies virus glycoprotein E/I complex in baculovirus recombinant system.
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General gene information

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Homology

Miscellaneous features

  • Loc: 123469-123469 experiment = approximation (+/- 20 nt) of transcriptional initation site from S1 mapping in strain In-Fh
  • Loc: 123484-123484 transcriptional initiation site inference = ab initio prediction:NNPP:
  • Loc: 125261-125261 transcriptional initiation site inference = ab initio prediction:NNPP:
  • Loc: 125726-125726 US2 experiment = approximation (+/- 10 nt) of transcriptional initation site from S1 mapping in strain NIA-3 , inference = ab initio prediction:NNPP:

polyA_site

  • Loc: 125732-125732 experiment = cDNA sequence in strain TNL

regulatory

  • Loc: 123452-123458 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
  • Loc: 125231-125237 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
  • Loc: 125697-125702 inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence
  • Loc: 125697-125703 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box

General protein information

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Preferred Names
envelope glycoprotein E
YP_068389.1
  • gE family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006151.1 Reference assembly

    Range
    123452..125732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_068389.1 envelope glycoprotein E [Suid alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_068389.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08354
    UniProtKB/TrEMBL
    Q5PP81, Q6UK11
    Conserved Domains (1) summary
    PHA03283
    Location:66 → 576
    PHA03283; envelope glycoprotein E; Provisional
Nucleotide Protein
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