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UL13 tegument serine/threonine protein kinase [ Suid alphaherpesvirus 1 ]

Gene ID: 2952530, updated on 18-Aug-2023

Summary

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Gene symbol
UL13
Gene description
tegument serine/threonine protein kinase
Locus tag
SuHV1_gp45
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_006151.1 (77272..80300)

NC_006151.1Genomic Context describing neighboring genes Neighboring gene major capsid protein Neighboring gene capsid triplex subunit 2 Neighboring gene DNA packaging terminase subunit 1 Neighboring gene DNA packaging tegument protein UL17 Neighboring gene tegument protein UL16 Neighboring gene tegument protein UL14 Neighboring gene deoxyribonuclease Neighboring gene myristylated tegument protein Neighboring gene envelope glycoprotein M Neighboring gene DNA replication origin-binding helicase Neighboring gene helicase-primase subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006151.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing. Van Cleemput J, et al. J Virol, 2021 Feb 24. PMID 33361431, Free PMC Article
  2. PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways. Lv L, et al. Vet Microbiol, 2020 Nov. PMID 33045632
  3. PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3. Bo Z, et al. Vet Res, 2020 Sep 15. PMID 32933581, Free PMC Article
  4. Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity. Lv L, et al. J Virol, 2021 Sep 9. PMID 34260286, Free PMC Article
  5. Complete, annotated sequence of the pseudorabies virus genome. Klupp BG, et al. J Virol, 2004 Jan. PMID 14671123, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxiredoxin 1 Interacts with TBK1/IKKepsilon and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
    Title: Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
  2. PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways.
    Title: PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways.
  3. CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing.
    Title: CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing.
  4. PRV UL13 inhibits cGAS-STING-mediated IFN-beta production by phosphorylating IRF3.
    Title: PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Submit: New GeneRIF Correction

General gene information

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Homology

Miscellaneous features

  • Loc: 77304-77304 transcriptional initiation site inference = ab initio prediction:NNPP:
  • Loc: 78351-78351 transcriptional initiation site inference = ab initio prediction:NNPP:
  • Loc: 78501-78501 experiment = approximation (+/- 8 nt) of transcriptional initation site from primer extension in strain TNL

polyA_site

  • Loc: 80300-80300 experiment = cDNA sequence in strain TNL (UL12)

regulatory

  • Loc: 77272-77278 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
  • Loc: 78322-78328 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
  • Loc: 80280-80285 experiment = consistent with mRNA sizes (sense unknown) in strain NIA-3 (UL14, UL13, UL12) , inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
tegument serine/threonine protein kinase
YP_068362.1
  • PK family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006151.1 Reference assembly

    Range
    77272..80300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_068362.1 tegument serine/threonine protein kinase [Suid alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_068362.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P30662
    UniProtKB/TrEMBL
    A0A172XDR8, G3G983, Q5PPE1
    Conserved Domains (1) summary
    COG0515
    Location:86 → 310
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version

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