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IE180 transcriptional regulator ICP4 [ Suid alphaherpesvirus 1 ]

Gene ID: 2952540, updated on 18-Aug-2023

Summary

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Gene symbol
IE180
Gene description
transcriptional regulator ICP4
Locus tag
SuHV1_gp63
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_006151.1 (102696..107804, complement)

NC_006151.1Genomic Context describing neighboring genes Neighboring gene protein V57 Neighboring gene nuclear protein UL3 Neighboring gene uracil-DNA glycosylase Neighboring gene envelope glycoprotein L Neighboring gene miscRNA Neighboring gene ubiquitin E3 ligase ICP0 Neighboring gene regulatory protein ICP22 Neighboring gene serine/threonine protein kinase US3 Neighboring gene envelope glycoprotein G

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006151.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a replication-incompetent pseudorabies virus mutant lacking the sole immediate early gene IE180. Wu BW, et al. mBio, 2014 Nov 11. PMID 25389174, Free PMC Article
  2. Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus. Lerma L, et al. Virus Res, 2020 Apr 2. PMID 32045631
  3. The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2α. Van Opdenbosch N, et al. J Virol, 2012 Jul. PMID 22532685, Free PMC Article
  4. Complete, annotated sequence of the pseudorabies virus genome. Klupp BG, et al. J Virol, 2004 Jan. PMID 14671123, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.
    Title: Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.
  2. IE180-null mutants failed to replicate new viral genomes, synthesize immediate early, early, or late viral proteins, and assemble infectious virions.
    Title: Characterization of a replication-incompetent pseudorabies virus mutant lacking the sole immediate early gene IE180.
  3. In conclusion, the immediate-early IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.
    Title: The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2α.
Submit: New GeneRIF Correction

General gene information

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regulatory

  • Loc: c102719-102714 experiment = consistent with mRNA size (sense unknown) in strain In-Fh , inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence
  • Loc: c107804-107798 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box

General protein information

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Preferred Names
transcriptional regulator ICP4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006151.1 Reference assembly

    Range
    102696..107804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_068382.1 transcriptional regulator ICP4 [Suid alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_068382.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P33479
    UniProtKB/TrEMBL
    A0A172XDM4, Q5PP75
    Conserved Domains (3) summary
    PHA03307
    Location:128 → 1351
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam03584
    Location:482 → 653
    Herpes_ICP4_N; Herpesvirus ICP4-like protein N-terminal region
    pfam03585
    Location:973 → 1350
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein
Heading Accession and Version

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