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Eif3m eukaryotic translation initiation factor 3, subunit M [ Rattus norvegicus (Norway rat) ]

Gene ID: 295975, updated on 17-Aug-2024

Summary

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Official Symbol
Eif3mprovided by RGD
Official Full Name
eukaryotic translation initiation factor 3, subunit Mprovided by RGD
Primary source
RGD:1565840
See related
EnsemblRapid:ENSRNOG00000012738 AllianceGenome:RGD:1565840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565840
Summary
Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Orthologous to human EIF3M (eukaryotic translation initiation factor 3 subunit M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 851.0), Thymus (RPKM 842.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111879589..111897193, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (91424754..91442358, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94990086..95007690, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17, pseudogene 17 Neighboring gene coiled-coil domain containing 73 Neighboring gene uncharacterized LOC134486134 Neighboring gene gamma-aminobutyric acid receptor-associated protein-like 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. Zeng L, et al. J Biol Chem, 2013 Oct 18. PMID 24003236, Free PMC Article
  2. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Lee AS, et al. Nature, 2015 Jun 4. PMID 25849773, Free PMC Article
  4. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Damoc E, et al. Mol Cell Proteomics, 2007 Jul. PMID 17322308
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Zhou M, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 18599441, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit M
NP_001161995.1
XP_038960460.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168523.1 → NP_001161995.1  eukaryotic translation initiation factor 3 subunit M isoform 1

    See identical proteins and their annotated locations for NP_001161995.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNV6, D3ZAZ0
    Related
    ENSRNOP00000017409.7, ENSRNOT00000017409.9
    Conserved Domains (1) summary
    smart00088
    Location:269 → 357
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

  2. NM_001429982.1 → NP_001416911.1  eukaryotic translation initiation factor 3 subunit M isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZR56

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    111879589..111897193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104532.2 → XP_038960460.1  eukaryotic translation initiation factor 3 subunit M isoform X1

    Conserved Domains (1) summary
    smart00088
    Location:206 → 294
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
Nucleotide Protein Strain
Heading Accession and Version

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