Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adh4provided by RGD
Official Full Name: alcohol dehydrogenase 4 (class II), pi polypeptideprovided by RGD
Primary source: RGD:71028
See related: EnsemblRapid:ENSRNOG00000046357 AllianceGenome:RGD:71028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ADH-1; Ac1002
Summary: Predicted to enable several functions, including NADPH:quinone reductase activity; alcohol dehydrogenase [NAD(P)+] activity; and retinoid binding activity. Involved in ovulation cycle and response to ethanol. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 190.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229622092..229640120)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226948717..226966747)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243702035..243720063)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe the expression patterns of alcohol dehydrogenases I, III, and IV in adult rat, mouse and human tissues using radioactive oligonucleotide in situ hybridization.
Title: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.
Cellular expression of Adh4 in the GI tract was studied.
Title: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.
activity and expression in gastrointestinal tissue homogenates
Title: Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables NADPH:quinone reductase activity	ISO Inferred from Sequence Orthology more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans retinal binding	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables benzaldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables retinol binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alcohol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in alcohol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aldehyde metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aldehyde metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ethanol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid omega-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid omega-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in formaldehyde catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ovulation cycle	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within quinone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: all-trans-retinol dehydrogenase [NAD(+)] ADH4

Names: ADH2; alcohol dehydrogenase 2; alcohol dehydrogenase 4-like; alcohol dehydrogenase II; alcohol dehydrogenase class II; class II alcohol dehydrogenase, pi subunit

NP_058966.2

EC 1.1.1.105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017270.2 → NP_058966.2 all-trans-retinol dehydrogenase [NAD(+)] ADH4

See identical proteins and their annotated locations for NP_058966.2

Status: PROVISIONAL

Source sequence(s)

BC127504

UniProtKB/Swiss-Prot

Q64563

UniProtKB/TrEMBL

A1L128

Related

ENSRNOP00000077866.1, ENSRNOT00000104576.2

Conserved Domains (1) summary

cd08299
Location:3 → 377

alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases