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Pnck pregnancy up-regulated nonubiquitous CaM kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 29660, updated on 10-Jul-2024

Summary

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Official Symbol
Pnckprovided by RGD
Official Full Name
pregnancy up-regulated nonubiquitous CaM kinaseprovided by RGD
Primary source
RGD:69249
See related
EnsemblRapid:ENSRNOG00000058317 AllianceGenome:RGD:69249
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Camk1b
Summary
Enables calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human PNCK (pregnancy up-regulated nonubiquitous CaM kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 79.3) See more
Orthologs
human mouse all
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Genomic context

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See Pnck in Genome Data Viewer
Location:
Xq37
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156520751..156524828, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151369406..151373508, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157150071..157154558)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28 like 2 Neighboring gene dual specificity phosphatase 9 Neighboring gene solute carrier family 6 member 8 Neighboring gene B-cell receptor-associated protein 31 Neighboring gene ATP binding cassette subfamily D member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isoform-specific activation and structural diversity of calmodulin kinase I. Naito Y, et al. J Biol Chem, 1997 Dec 19. PMID 9405489
  2. Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms. Tokumitsu H, et al. Biochemistry, 2001 Nov 20. PMID 11705382
  3. Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms. Yokokura H, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074610
  4. Ca(2+)/CaM-dependent kinases: from activation to function. Hook SS, et al. Annu Rev Pharmacol Toxicol, 2001. PMID 11264466
  5. Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Yurimoto S, et al. Biochemistry, 2009 May 12. PMID 19292454

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1B
Names
Protein Kinase-like
caM kinase I beta
caM kinase IB
caM-KI beta
caMKI-beta
calcium/calmodulin-dependent protein kinase 1, beta
pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog
pregnancy upregulated non-ubiquitously expressed CaM kinase
NP_058971.1
XP_006229634.1
XP_006229635.1
XP_006229637.1
XP_008771850.1
XP_063135942.1
XP_063135943.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017275.2 → NP_058971.1  calcium/calmodulin-dependent protein kinase type 1B

    See identical proteins and their annotated locations for NP_058971.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    O08767, O70150
    UniProtKB/TrEMBL
    A6KRX2, A6KRX3
    Related
    ENSRNOP00000074179.1, ENSRNOT00000090795.3
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    156520751..156524828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229573.5 → XP_006229635.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_006229635.1

    UniProtKB/Swiss-Prot
    O08767, O70150
    UniProtKB/TrEMBL
    A6KRX2, A6KRX3
    Related
    ENSRNOP00000094811.1, ENSRNOT00000095467.2
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  2. XM_063279872.1 → XP_063135942.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    O08767, O70150
    UniProtKB/TrEMBL
    A6KRX2, A6KRX3

  3. XM_006229572.5 → XP_006229634.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    See identical proteins and their annotated locations for XP_006229634.1

    UniProtKB/TrEMBL
    A6KRX1, A6KRX2
    Conserved Domains (2) summary
    smart00220
    Location:18 → 273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:14 → 290
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  4. XM_063279873.1 → XP_063135943.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

    UniProtKB/TrEMBL
    A6KRX2

  5. XM_006229575.5 → XP_006229637.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_006229637.1

    UniProtKB/Swiss-Prot
    O08767, O70150
    UniProtKB/TrEMBL
    A6KRX2, A6KRX3
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  6. XM_008773628.4 → XP_008771850.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_008771850.1

    UniProtKB/Swiss-Prot
    O08767, O70150
    UniProtKB/TrEMBL
    A6KRX2, A6KRX3
    Related
    ENSRNOP00000099713.1, ENSRNOT00000126122.1
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70150.1 GenPept UniProtKB/Swiss-Prot:O70150

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