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Ptprn2 protein tyrosine phosphatase, receptor type N2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29714, updated on 14-Nov-2024

Summary

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Official Symbol
Ptprn2provided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type N2provided by RGD
Primary source
RGD:61904
See related
EnsemblRapid:ENSRNOG00000005003 AllianceGenome:RGD:61904
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PTPNE6; R-PTP-N2
Summary
Predicted to enable protein tyrosine phosphatase activity. Involved in negative regulation of GTPase activity. Located in endoplasmic reticulum lumen; secretory granule; and terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 258.7) and Adrenal (RPKM 24.0) See more
Orthologs
human mouse all
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Genomic context

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See Ptprn2 in Genome Data Viewer
Location:
6q33
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143582568..144334573)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137439572..138191575)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144384773..145133042)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene non-SMC condensin II complex, subunit G2 Neighboring gene uncharacterized LOC102548847 Neighboring gene uncharacterized LOC120093226 Neighboring gene uncharacterized LOC108351315 Neighboring gene uncharacterized LOC134479492 Neighboring gene uncharacterized LOC134479491 Neighboring gene uncharacterized LOC120093227 Neighboring gene microRNA 153 Neighboring gene lactate dehydrogenase A, pseudogene 25 Neighboring gene uncharacterized LOC120093171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knockdown of Ptprn-2 delays the onset of puberty in female rats. Kang T, et al. Theriogenology, 2021 Dec. PMID 34607132
  2. Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives. Achenbach P, et al. Diabetologia, 2008 Mar. PMID 18193190
  3. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. Kelemen K, et al. J Immunol, 2004 Mar 15. PMID 15004204
  4. Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. Achenbach P, et al. J Autoimmun, 2002 Nov. PMID 12419281
  5. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons. Jiang S, et al. Gene, 1998 Jul 30. PMID 9714834

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of Ptprn-2 delays the onset of puberty in female rats.
    Title: Knockdown of Ptprn-2 delays the onset of puberty in female rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase N2
Names
PTP NE-6
phogrin
protein tyrosine phosphatase receptor-type N polypeptide 2
NP_113788.1
XP_038967789.1
XP_038967790.1
XP_038967791.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031600.2 → NP_113788.1  receptor-type tyrosine-protein phosphatase N2 precursor

    See identical proteins and their annotated locations for NP_113788.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q63475
    UniProtKB/TrEMBL
    A6KDL9
    Related
    ENSRNOP00000110350.1, ENSRNOT00000160214.1
    Conserved Domains (4) summary
    smart00194
    Location:734 → 993
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:761 → 993
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:501 → 586
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:58 → 113
    RESP18; RESP18 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    143582568..144334573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111861.2 → XP_038967789.1  receptor-type tyrosine-protein phosphatase N2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHT8
    Related
    ENSRNOP00000093030.1, ENSRNOT00000116222.2
    Conserved Domains (3) summary
    cd14610
    Location:738 → 1020
    R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
    pfam11548
    Location:520 → 608
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:80 → 148
    RESP18; RESP18 domain

  2. XM_039111863.2 → XP_038967791.1  receptor-type tyrosine-protein phosphatase N2 isoform X3

    Conserved Domains (3) summary
    cd14610
    Location:670 → 952
    R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
    pfam11548
    Location:452 → 540
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:80 → 148
    RESP18; RESP18 domain

  3. XM_039111862.2 → XP_038967790.1  receptor-type tyrosine-protein phosphatase N2 isoform X2

    Related
    ENSRNOP00000006942.5, ENSRNOT00000006942.6
    Conserved Domains (3) summary
    cd14610
    Location:699 → 981
    R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
    pfam11548
    Location:481 → 569
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:41 → 96
    RESP18; RESP18 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63475.1 GenPept UniProtKB/Swiss-Prot:Q63475

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