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Klra5 killer cell lectin-like receptor, subfamily A, member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297666, updated on 17-Aug-2024

Summary

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Symbol
Klra5provided by RGD
Full Name
killer cell lectin-like receptor, subfamily A, member 5provided by RGD
Primary source
RGD:735134
See related
EnsemblRapid:ENSRNOG00000061664 AllianceGenome:RGD:735134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ly-49.9
Summary
Involved in natural killer cell activation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 28.0), Lung (RPKM 17.4) and 7 other tissues See more
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Genomic context

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Location:
4q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166491210..166556087, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (164761839..164824367, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (165169417..165317573, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ly49 stimulatory receptor 8 Neighboring gene peptidyl-prolyl cis-trans isomerase D pseudogene Neighboring gene killer cell lectin-like receptor 4 Neighboring gene Ly49 stimulatory receptor 7 Neighboring gene Ly49 inhibitory receptor 7 Neighboring gene killer cell lectin-like receptor, subfamily A, member 2 Neighboring gene uncharacterized LOC108350878

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Dissen E, et al. J Exp Med, 1996 May 1. PMID 8642329, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
killer cell lectin-like receptor, subfamily A, member 5
Names
Ly-49.9 antigen
killer cell lectin-like receptor 5
killer cell lectin-like receptor 5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198746.4 → NP_942041.3  killer cell lectin-like receptor, subfamily A, member 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IM90, E9PTN0, Q62982
    Related
    ENSRNOP00000065392.3, ENSRNOT00000073877.3
    Conserved Domains (2) summary
    cd03593
    Location:145 → 260
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:40 → 157
    Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    166491210..166556087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285916.1 → XP_063141986.1  killer cell lectin-like receptor, subfamily A, member 5 isoform X2

    UniProtKB/TrEMBL
    Q62982

  2. XM_039107455.2 → XP_038963383.1  killer cell lectin-like receptor, subfamily A, member 5 isoform X1

    Related
    ENSRNOP00000069231.4, ENSRNOT00000087529.4
    Conserved Domains (2) summary
    cd03593
    Location:211 → 326
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:106 → 223
    Ly49; Ly49-like protein, N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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