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Wbp11 WW domain binding protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297695, updated on 17-Aug-2024

Summary

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Official Symbol
Wbp11provided by RGD
Official Full Name
WW domain binding protein 11provided by RGD
Primary source
RGD:1307911
See related
EnsemblRapid:ENSRNOG00000005505 AllianceGenome:RGD:1307911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
wbp-11; Wbp11l1
Summary
Predicted to enable WW domain binding activity and protein phosphatase regulator activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to act upstream of or within RNA splicing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of spliceosomal complex. Orthologous to human WBP11 (WW domain binding protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 141.4), Thymus (RPKM 120.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wbp11 in Genome Data Viewer
Location:
4q43
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171412187..171425634, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169680984..169694431, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170772166..170785613, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486649 Neighboring gene H2A.J histone Neighboring gene single-pass membrane protein with coiled-coil domains 3 like 1 Neighboring gene sorbitol dehydrogenase-like Neighboring gene similar to human chromosome 12 open reading frame 60 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene ADP-ribosyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). Huang X, et al. J Biol Chem, 2009 Sep 11. PMID 19592703, Free PMC Article
  2. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Llorian M, et al. Biochem J, 2004 Feb 15. PMID 14640981, Free PMC Article
  3. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Ivatt RM, et al. Proc Natl Acad Sci U S A, 2014 Jun 10. PMID 24912190, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94547

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WW domain-binding protein 11
Names
WW domain-binding protein 11-like 1
splicing factor that interacts with PQBP-1 and PP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009661.2 → NP_001009661.1  WW domain-binding protein 11

    See identical proteins and their annotated locations for NP_001009661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC087082, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5PQQ2
    UniProtKB/TrEMBL
    A0A0G2JUA6, A6IMI5
    Conserved Domains (1) summary
    pfam09429
    Location:12 → 92
    Wbp11; WW domain binding protein 11

  2. NM_001303017.1 → NP_001289946.1  WW domain-binding protein 11

    See identical proteins and their annotated locations for NP_001289946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC087082, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5PQQ2
    UniProtKB/TrEMBL
    A0A0G2JUA6, A6IMI5
    Related
    ENSRNOP00000007402.5, ENSRNOT00000007402.7
    Conserved Domains (1) summary
    pfam09429
    Location:12 → 92
    Wbp11; WW domain binding protein 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    171412187..171425634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQQ2.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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