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Mup4l1 major urinary protein 4 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298109, updated on 10-Jul-2024

Summary

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Official Symbol
Mup4l1provided by RGD
Official Full Name
major urinary protein 4 like 1provided by RGD
Primary source
RGD:1566134
See related
EnsemblRapid:ENSRNOG00000083187 AllianceGenome:RGD:1566134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mup; Mup4l2; RGD1566134
Summary
Predicted to enable pheromone binding activity and small molecule binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 19928.7) See more
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Genomic context

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See Mup4l1 in Genome Data Viewer
Location:
5q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80223093..80226566, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75221340..75224797, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (77430657..77433866, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene major urinary protein-like Neighboring gene major urinary protein-like Neighboring gene zinc finger protein 37, pseudogene 5 Neighboring gene zinc finger protein 37-like Neighboring gene major urinary protein 4 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Borghoff SJ, et al. Toxicology, 2015 Jul 3. PMID 25797582
  2. Purification and identification of allergenic alpha (2u)-globulin species of rat urine. Bayard C, et al. Biochim Biophys Acta, 1996 Jun 4. PMID 8645715
  3. Male urinary protein-1 (Mup-1) expression in the female rat. Kondo Y, et al. J Hered, 1983 Jul-Aug. PMID 6886376
  4. The structure and expression of very closely related members of the alpha 2u globulin gene family. Dolan KP, et al. J Biol Chem, 1982 Nov 25. PMID 6183262
  5. Cloning and sequence of several alpha 2u-globulin cDNAs. Unterman RD, et al. Proc Natl Acad Sci U S A, 1981 Jun. PMID 6167987, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methyl isobutyl ketone exerts nephrotoxic effects through a protein droplet alpha2u nephropathy-mediated mode of action.
    Title: Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding.
Submit: New GeneRIF Correction

General gene information

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Markers

Clone Names

  • MGC112596, MGC124936

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables insulin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pheromone binding IEA
Inferred from Electronic Annotation
more info
  
enables pheromone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to lipid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in energy reserve metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heat generation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
major urinary protein
Names
allergen Rat n I
allergen n I
alpha(2)-euglobulin
alpha-2u globulin PGCL1
alpha-2u globulin PGCL2
alpha-2u-globulin
alpha-2u-globulin (L type)
major urinary protein 4 like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003409.2 → NP_001003409.2  major urinary protein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P02761, Q54AE7
    UniProtKB/TrEMBL
    A6KUS2, F1LQM1, Q9JJI4
    Related
    ENSRNOP00000067914.3, ENSRNOT00000076791.4

  2. NM_203512.3 → NP_988843.3  major urinary protein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P02761, Q54AE7
    UniProtKB/TrEMBL
    A6KUS2, F1LQM1, Q9JJI4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    80223093..80226566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109479.2 → XP_038965407.1  major urinary protein isoform X1

    UniProtKB/Swiss-Prot
    P02761, Q54AE7
    UniProtKB/TrEMBL
    A6KUS2, F1LQM1, Q9JJI4
    Conserved Domains (1) summary
    cd19428
    Location:24 → 181
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

  2. XM_039109481.2 → XP_038965409.1  major urinary protein isoform X1

    UniProtKB/Swiss-Prot
    P02761, Q54AE7
    UniProtKB/TrEMBL
    A6KUS2, F1LQM1, Q9JJI4
    Conserved Domains (1) summary
    cd19428
    Location:24 → 181
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

  3. XM_039109483.2 → XP_038965411.1  major urinary protein isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:15 → 119
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02761.1 GenPept UniProtKB/Swiss-Prot:P02761

Gene LinkOut

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