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Nubpl NUBP iron-sulfur cluster assembly factor like [ Rattus norvegicus (Norway rat) ]

Gene ID: 299008, updated on 10-Oct-2024

Summary

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Official Symbol
Nubplprovided by RGD
Official Full Name
NUBP iron-sulfur cluster assembly factor likeprovided by RGD
Primary source
RGD:1307232
See related
EnsemblRapid:ENSRNOG00000027444 AllianceGenome:RGD:1307232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307232
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly; mitochondrial respiratory chain complex I assembly; and mitochondrion morphogenesis. Predicted to be located in plasma membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 21. Orthologous to human NUBPL (nucleotide binding protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 195.1), Heart (RPKM 57.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nubpl in Genome Data Viewer
Location:
6q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75294609..75516603)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69559278..69781254)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72891758..73147837)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 33, pseudogene 1 Neighboring gene D-aminoacyl-tRNA deacylase 2 Neighboring gene tensin-2 pseudogene Neighboring gene ceramide synthase 5, pseudogene 1 Neighboring gene uncharacterized LOC134479384

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Sheftel AD, et al. Mol Cell Biol, 2009 Nov. PMID 19752196, Free PMC Article
  2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
iron-sulfur cluster transfer protein NUBPL
Names
iron-sulfur protein NUBPL
nucleotide binding protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185025.1 → NP_001171954.1  iron-sulfur cluster transfer protein NUBPL precursor

    Status: VALIDATED

    Source sequence(s)
    BF282469, BP486352, CO399813
    UniProtKB/TrEMBL
    D3ZFQ3
    Related
    ENSRNOP00000097251.2, ENSRNOT00000097874.2
    Conserved Domains (2) summary
    COG0489
    Location:13 → 284
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    pfam10609
    Location:65 → 311
    ParA; NUBPL iron-transfer P-loop NTPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    75294609..75516603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764655.4 → XP_008762877.1  iron-sulfur cluster transfer protein NUBPL isoform X8

    UniProtKB/TrEMBL
    A0A8I6ARC8
    Conserved Domains (2) summary
    TIGR01969
    Location:17 → 267
    minD_arch; cell division ATPase MinD, archaeal
    pfam10609
    Location:13 → 259
    ParA; NUBPL iron-transfer P-loop NTPase

  2. XM_039111969.2 → XP_038967897.1  iron-sulfur cluster transfer protein NUBPL isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:65 → 231
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_063261670.1 → XP_063117740.1  iron-sulfur cluster transfer protein NUBPL isoform X4

  4. XM_039111970.2 → XP_038967898.1  iron-sulfur cluster transfer protein NUBPL isoform X5

    Conserved Domains (1) summary
    cl38936
    Location:65 → 171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_063261671.1 → XP_063117741.1  iron-sulfur cluster transfer protein NUBPL isoform X6

  6. XM_063261668.1 → XP_063117738.1  iron-sulfur cluster transfer protein NUBPL isoform X2

  7. XM_063261669.1 → XP_063117739.1  iron-sulfur cluster transfer protein NUBPL isoform X3

  8. XM_063261672.1 → XP_063117742.1  iron-sulfur cluster transfer protein NUBPL isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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