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OBP2B odorant binding protein 2B [ Homo sapiens (human) ]

Gene ID: 29989, updated on 10-Dec-2024

Summary

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Official Symbol
OBP2Bprovided by HGNC
Official Full Name
odorant binding protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:23381
See related
Ensembl:ENSG00000171102 MIM:604606; AllianceGenome:HGNC:23381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCN14; OBPIIb
Summary
Predicted to enable small molecule binding activity. Predicted to be involved in chemosensory behavior. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis (RPKM 3.3) See more
Orthologs
mouse all
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Genomic context

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See OBP2B in Genome Data Viewer
Location:
9q34.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133205279..133223255, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145418863..145436839, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136080666..136084637, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:135976589-135977788 Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135995531-135996227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:136002206-136003405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136008097-136008641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136019197-136019756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136024237-136024884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136038755-136039477 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136062831-136063698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136075403-136076124 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136081856-136082043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136102720-136103675 Neighboring gene uncharacterized LOC124902294 Neighboring gene lipocalin 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B. Sano R, et al. Sci Rep, 2021 Apr 1. PMID 33795748, Free PMC Article
  2. Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. Briand L, et al. Biochemistry, 2002 Jun 11. PMID 12044155
  3. A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. Lacazette E, et al. Hum Mol Genet, 2000 Jan 22. PMID 10607840
  4. Molecular cloning of odorant-binding protein: member of a ligand carrier family. Pevsner J, et al. Science, 1988 Jul 15. PMID 3388043
  5. Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Desch KC, et al. Proc Natl Acad Sci U S A, 2013 Jan 8. PMID 23267103, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B.
    Title: A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables odorant binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemosensory behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in sensory perception of smell NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
odorant-binding protein 2b
Names
odorant-binding protein IIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288987.2 → NP_001275916.1  odorant-binding protein 2b precursor

    See identical proteins and their annotated locations for NP_001275916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and alpha encode the same protein.
    Source sequence(s)
    AI251747, BC098340, HY046406
    Consensus CDS
    CCDS6961.1
    UniProtKB/Swiss-Prot
    Q5VSP6, Q9NPH6, Q9NY51, Q9NY52
    UniProtKB/TrEMBL
    Q2PAD7
    Related
    ENSP00000484615.1, ENST00000618116.4
    Conserved Domains (1) summary
    pfam00061
    Location:26 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_014581.4 → NP_055396.1  odorant-binding protein 2b precursor

    See identical proteins and their annotated locations for NP_055396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (alpha, PMID:10607840) differs in the 3' UTR, compared to variant 1. Variants 1 and alpha encode the same protein.
    Source sequence(s)
    AI251747, AY358981, HY046406
    Consensus CDS
    CCDS6961.1
    UniProtKB/Swiss-Prot
    Q5VSP6, Q9NPH6, Q9NY51, Q9NY52
    UniProtKB/TrEMBL
    Q2PAD7
    Related
    ENSP00000361104.3, ENST00000372034.8
    Conserved Domains (1) summary
    pfam00061
    Location:26 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. NR_110242.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (beta, PMID:10607840) contains an alternate exon and differs in the 3' UTR, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI251747, AJ251027, HY046406
    Related
    ENST00000473737.5

  2. NR_110243.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (gamma, PMID:10607840) lacks an alternate exon and differs in the 3' UTR, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI251747, AJ251028, BX101545, HY046406
    Related
    ENST00000461961.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133205279..133223255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423295.1 → XP_047279251.1  odorant-binding protein 2b isoform X1

  2. XM_017014654.2 → XP_016870143.1  odorant-binding protein 2b isoform X1

    Conserved Domains (1) summary
    pfam00061
    Location:78 → 216
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  3. XM_006717086.4 → XP_006717149.1  odorant-binding protein 2b isoform X2

    See identical proteins and their annotated locations for XP_006717149.1

    UniProtKB/TrEMBL
    Q2PAD7
    Conserved Domains (1) summary
    pfam00061
    Location:1 → 131
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p14 PATCHES

    Range
    31225..49201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331580.1 → XP_054187555.1  odorant-binding protein 2b isoform X1

  2. XM_054331581.1 → XP_054187556.1  odorant-binding protein 2b isoform X2

    UniProtKB/TrEMBL
    Q2PAD7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145418863..145436839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362851.1 → XP_054218826.1  odorant-binding protein 2b isoform X1

  2. XM_054362850.1 → XP_054218825.1  odorant-binding protein 2b isoform X1

  3. XM_054362852.1 → XP_054218827.1  odorant-binding protein 2b isoform X2

    UniProtKB/TrEMBL
    Q2PAD7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPH6.1 GenPept UniProtKB/Swiss-Prot:Q9NPH6

Gene LinkOut

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